Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa.
Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa.
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DOI：
10.1371/journal.pntd.0006347
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发表时间：
2018-03
影响因子：
3.8
通讯作者：
Fuimaono S
中科院分区：
文献类型：
--
作者：
Won KY;Robinson K;Hamlin KL;Tufa J;Seespesara M;Wiegand RE;Gass K;Kubofcik J;Nutman TB;Lammie PJ;Fuimaono S
Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activities beyond the recommended transmission assessment survey (TAS). TAS was first conducted in American Samoa in 2011 (TAS 1) and a repeat TAS was carried out in 2015 (TAS 2). Circulating filarial antigen (CFA) and serologic results from both surveys were analyzed to determine whether interruption of LF transmission has been achieved in American Samoa. A total of 1,134 and 864 children (5–10 years old) were enrolled in TAS 1 and TAS 2, respectively. Two CFA-positive children were identified in TAS 1, and one CFA-positive child was identified in TAS 2. Results of both surveys were below the threshold for which MDA was warranted. Additionally, 1,112 and 836 dried blood spots from TAS 1 and TAS 2, respectively were tested for antibodies to Wb123, Bm14 and Bm33 by luciferase immunoprecipitation system (LIPS) assay and multiplex bead assay. In 2011, overall prevalence of responses to Wb123, Bm14, and Bm33 was 1.0%, 6.8% and 12.0%, respectively. In 2015, overall prevalence of positive Bm14 and Bm33 responses declined significantly to 3.0% (p<0.001) and 7.8% (p = 0.013), respectively. Although passing TAS 1 and TAS 2 and an overall decline in the prevalence of antibodies to Bm14 and Bm33 between these surveys suggests decreased exposure and infection among young children, there were persistent responses in some schools. Clustering and persistence of positive antibody responses in schools may be an indication of ongoing transmission. There is a need to better understand the limitations of current antibody tests, but our results suggest that serologic tools can have a role in guiding programmatic decision making. Lymphatic filariasis (LF), endemic in 72 countries, is a debilitating mosquito-transmitted parasitic disease caused by filarial worms. The Global Program to Eliminate Lymphatic Filariasis (GPELF) aims to interrupt transmission through mass drug administration (MDA) and to reduce suffering caused by the disease. At the start of GPELF in 2000 it was estimated that approximately 1.4 billion people were at risk for infection. By the end of 2016, primarily through successful MDA programs, the global number of people requiring interventions was reduced to 856.4 million. Current recommendations by the World Health Organization for LF surveillance advise programs to implement activities to monitor for new foci of transmission after stopping MDA. A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activities beyond the recommended transmission assessment survey (TAS). Two TAS were conducted in American Samoa; first in 2011 (TAS 1) and repeated in 2015 (TAS 2). In our evaluation, circulating filarial antigen and serologic results from both surveys were analyzed to determine whether interruption of LF transmission has been achieved in American Samoa. Despite passing TAS 1 and TAS 2, clustering and persistence of positive antibody responses in schools may be an indication of ongoing transmission. Results from our evaluation suggest that serologic tools can have a role in guiding programmatic decision-making.
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影响因子：
4.5
作者：
Coutts SP;King JD;Pa'au M;Fuimaono S;Roth J;King MR;Lammie PJ;Lau CL;Graves PM
通讯作者：
Graves PM
影响因子：
3.8
作者：
Schmaedick MA;Koppel AL;Pilotte N;Torres M;Williams SA;Dobson SL;Lammie PJ;Won KY
通讯作者：
Won KY
DOI：
10.1186/1475-2883-3-9
发表时间：
2004-09-03
期刊：
Filaria journal
影响因子：
--
作者：
Lammie, Patrick J;Weil, Gary;Ottesen, Eric
通讯作者：
Ottesen, Eric
影响因子：
2.7
作者：
Weil, Gary J.;Curtis, Kurt C.;Brattig, Norbert W.
通讯作者：
Brattig, Norbert W.
DOI：
10.4269/ajtmh.2008.78.924
发表时间：
2008-06-01
影响因子：
3.3
作者：
Liang, Jennifer L.;King, Jonathan D.;Lammie, Patrick J.
通讯作者：
Lammie, Patrick J.