Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes.
Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes.
复制标题
精神病生物型中的大脑结构生物标志物：中间表型的双极 - 奇异性网络的发现。
DOI：
10.1016/j.biopsych.2016.08.030
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发表时间：
2017-07-01
影响因子：
10.6
通讯作者：
Tamminga CA
中科院分区：
文献类型：
--
作者：
Ivleva EI;Clementz BA;Dutcher AM;Arnold SJM;Jeon-Slaughter H;Aslan S;Witte B;Poudyal G;Lu H;Meda SA;Pearlson GD;Sweeney JA;Keshavan MS;Tamminga CA
目前对精神病的定义缺乏生物学有效性，激发了替代生物标志物驱动的疾病实体。我们以先前根据认知和神经生理学测量开发的实验结构（生物型）为基础，将不同生物型的大脑解剖特征与传统诊断进行对比，检查灰质密度（GMD）作为生物型的独立验证器。在 Biotype 组织的先证者、其亲属和健康受试者中检查全脑 GMD 测量，然后使用基于体素的形态测量法进行 DSM-IV-TR 诊断 (n = 1409)，并随后进行受试者级区域特征和分布分析。按 Biotype 与健康对照分组的先证者显示 GMD 降低的逐步模式如下： Biotype1，广泛且分散分布的 GMD 降低，对额叶、前/中扣带皮层和颞区影响最大； Biotype2，中间和更局部的减少，对岛叶和额颞叶区域影响最大； Biotype3，小幅减少局限于前边缘区域。与健康对照组相比，亲属表现出区域性不同的 GMD 降低，主要是 Biotype1 中的前部（额颞叶）效应； Biotype2 中的后部（颞顶小脑）； Biotype3 中 GMD 正常。与健康对照相比，精神分裂症和分裂情感先证者表现出重叠的 GMD 降低，其中额颞叶和顶叶区域的影响最大；精神病性双相情感障碍先证者有小幅减少，主要是在额叶区域。亲属的 GMD 变化遵循先证者观察到的区域模式，尽管范围较小。基于 GMD 的生物型显示出比传统诊断更强的组间分离，并且是 GMD 变化的最强预测因子。 GMD 生物标志物描绘了生物型中独特的大脑结构特征，与其认知和感觉运动特征一致，并为生物驱动的生物型提供了比基于症状的诊断更强的辨别力。
The current definitions of psychotic illness lack biological validity, motivating alternative biomarker-driven disease entities. Building on experimental constructs—Biotypes—that were previously developed from cognitive and neurophysiologic measures, we contrast brain anatomy characteristics across Biotypes alongside conventional diagnoses, examining gray matter density (GMD) as an independent validator for the Biotypes. Whole brain GMD measures were examined in probands, their relatives, and healthy subjects organized by Biotype and then by DSM-IV-TR diagnosis (n = 1409) using voxel-based morphometry with subsequent subject-level regional characterization and distribution analyses. Probands grouped by Biotype versus healthy controls showed a stepwise pattern of GMD reductions as follows: Biotype1, extensive and diffusely distributed GMD loss, with the largest effects in frontal, anterior/middle cingulate cortex, and temporal regions; Biotype2, intermediate and more localized reductions, with the largest effects in insula and frontotemporal regions; and Biotype3, small reductions localized to anterior limbic regions. Relatives showed regionally distinct GMD reductions versus healthy controls, with primarily anterior (frontotemporal) effects in Biotype1; posterior (temporo-parieto-cerebellar) in Biotype2; and normal GMD in Biotype3. Schizophrenia and schizoaffective probands versus healthy controls showed overlapping GMD reductions, with the largest effects in frontotemporal and parietal regions; psychotic bipolar probands had small reductions, primarily in frontal regions. GMD changes in relatives followed regional patterns observed in probands, albeit less extensive. Biotypes showed stronger between-group separation based on GMD than the conventional diagnoses and were the strongest predictor of GMD change. GMD biomarkers depicted unique brain structure characteristics within Biotypes, consistent with their cognitive and sensorimotor profiles, and provided stronger discrimination for biologically driven biotypes than symptom-based diagnoses.
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DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Clementz BA;Sweeney JA;Hamm JP;Ivleva EI;Ethridge LE;Pearlson GD;Keshavan MS;Tamminga CA
通讯作者：
Tamminga CA
DOI：
10.1017/s1355617710001189
发表时间：
2011-01
影响因子：
2.6
作者：
de la Plata, Carlos D. Marquez;Yang, Fanpei Gloria;Wang, Jun Yi;Krishnan, Kamini;Bakhadirov, Khamid;Paliotta, Christopher;Aslan, Sina;Devous, Michael D., Sr.;Moore, Carol;Harper, Caryn;McColl, Roderick;Cullum, C. Munro;Diaz-Arrastia, Ramon
通讯作者：
Diaz-Arrastia, Ramon
DOI：
10.1016/s0926-6410(02)00147-7
发表时间：
2003-01-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Dien, J;Frishkoff, GA;Tucker, DM
通讯作者：
Tucker, DM
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon