Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound.
Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound.
复制标题
磁共振与CT在经颅聚焦超声中矫正颅骨诱发位相像差的比较。
DOI：
10.1038/s41598-022-17319-4
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发表时间：
2022-08-04
影响因子：
4.6
通讯作者：
Pauly, Kim Butts
中科院分区：
文献类型：
--
作者：
Leung, Steven A.;Moore, David;Gilbo, Yekaterina;Snell, John;Webb, Taylor D.;Meyer, Craig H.;Miller, G. Wilson;Ghanouni, Pejman;Pauly, Kim Butts
InSightec Exablate系统的经颅聚焦超声使用热消融治疗运动和情绪障碍，并破坏血脑屏障进行肿瘤治疗。该系统使用计算机断层扫描（CT）图像来计算相位校正，该相位校正说明了由人类头骨引起的像差。这项工作调查磁共振（MR）图像是否可以作为一种替代CT图像来计算相位校正。使用金标准水听器方法和护理标准InSightec射线追踪方法计算相位校正。将三个离体人颅骨的MR二值图像掩模、MR模拟CT（MRsimCT）和CT图像作为InSightec射线追踪方法的输入。用670 kHz半球形相控阵换能器（InSightec Exablate 4000）超声处理脱气的离体人颅骨。使用安装在3轴定位器系统上的水听器获取束轮廓的3D光栅扫描。使用六个指标评价焦点：靶点处的压力、峰值压力、靶点处的强度、峰值强度、定位误差和焦点体积。研究了几何焦点处和几何焦点外侧5 mm处的靶点。使用MRsimCT或CT进行相位畸变校正时，任一靶点的任何指标之间均无统计学差异。与MRsimCT相反，使用CT图像进行像差校正需要与治疗日MR图像配准;沿沿着三维旋转误差在± 2度范围内的CT配准不良可使焦斑强度降低9.4%。用于颅骨相位畸变校正的MRsimCT图像产生与基于CT的校正类似的结果，同时避免CT到MR配准误差和不必要的患者暴露于电离辐射。
Transcranial focused ultrasound with the InSightec Exablate system uses thermal ablation for the treatment of movement and mood disorders and blood brain barrier disruption for tumor therapy. The system uses computed tomography (CT) images to calculate phase corrections that account for aberrations caused by the human skull. This work investigates whether magnetic resonance (MR) images can be used as an alternative to CT images to calculate phase corrections. Phase corrections were calculated using the gold standard hydrophone method and the standard of care InSightec ray tracing method. MR binary image mask, MR-simulated-CT (MRsimCT), and CT images of three ex vivo human skulls were supplied as inputs to the InSightec ray tracing method. The degassed ex vivo human skulls were sonicated with a 670 kHz hemispherical phased array transducer (InSightec Exablate 4000). 3D raster scans of the beam profiles were acquired using a hydrophone mounted on a 3-axis positioner system. Focal spots were evaluated using six metrics: pressure at the target, peak pressure, intensity at the target, peak intensity, positioning error, and focal spot volume. Targets at the geometric focus and 5 mm lateral to the geometric focus were investigated. There was no statistical difference between any of the metrics at either target using either MRsimCT or CT for phase aberration correction. As opposed to the MRsimCT, the use of CT images for aberration correction requires registration to the treatment day MR images; CT misregistration within a range of ± 2 degrees of rotation error along three dimensions was shown to reduce focal spot intensity by up to 9.4%. MRsimCT images used for phase aberration correction for the skull produce similar results as CT-based correction, while avoiding both CT to MR registration errors and unnecessary patient exposure to ionizing radiation.
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