Transcranial focused ultrasound stimulation of human primary visual cortex.
Transcranial focused ultrasound stimulation of human primary visual cortex.
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DOI：
10.1038/srep34026
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发表时间：
2016-09-23
影响因子：
4.6
通讯作者：
Yoo SS
中科院分区：
文献类型：
--
作者：
Lee W;Kim HC;Jung Y;Chung YA;Song IU;Lee JH;Yoo SS
经颅聚焦超声（FUS）作为一种新的非侵入性局部脑刺激模式正在取得进展。目前，FUS介导的人类神经刺激的证据仅限于主观感觉表现和电生理反应的观察，因此无法识别受刺激的大脑区域。在这里，我们报告FUS超声处理的初级视觉皮层（V1）在人类中，引起激活不仅从超声处理的大脑区域，但也从网络的区域参与视觉和高阶认知过程（如血液氧合水平依赖性功能磁共振成像的同时收购所揭示的）。还报告了伴随的光幻视感知。脑电（EEG）反应显示出与刺激相关的明显峰值。根据神经影像学和神经学检查，没有参与者显示出超声处理的任何不良反应。回顾性数值模拟的声学配置文件显示存在的个体差异的声学焦点的位置和强度。FUS具有精细的空间选择性和深度穿透能力，可在神经科学和治疗应用中提供区域特异性脑回路的非侵入性刺激方面具有独特的实用性。
Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of regional brain stimulation. Current evidence of FUS-mediated neurostimulation for humans has been limited to the observation of subjective sensory manifestations and electrophysiological responses, thus warranting the identification of stimulated brain regions. Here, we report FUS sonication of the primary visual cortex (V1) in humans, resulting in elicited activation not only from the sonicated brain area, but also from the network of regions involved in visual and higher-order cognitive processes (as revealed by simultaneous acquisition of blood-oxygenation-level-dependent functional magnetic resonance imaging). Accompanying phosphene perception was also reported. The electroencephalo graphic (EEG) responses showed distinct peaks associated with the stimulation. None of the participants showed any adverse effects from the sonication based on neuroimaging and neurological examinations. Retrospective numerical simulation of the acoustic profile showed the presence of individual variability in terms of the location and intensity of the acoustic focus. With exquisite spatial selectivity and capability for depth penetration, FUS may confer a unique utility in providing non-invasive stimulation of region-specific brain circuits for neuroscientific and therapeutic applications.
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