SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes.
SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes.
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DOI：
10.1016/j.jinf.2020.05.073
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Sharp DJ
中科院分区：
文献类型：
--
作者：
Graham NSN;Junghans C;Downes R;Sendall C;Lai H;McKirdy A;Elliott P;Howard R;Wingfield D;Priestman M;Ciechonska M;Cameron L;Storch M;Crone MA;Freemont PS;Randell P;McLaren R;Lang N;Ladhani S;Sanderson F;Sharp DJ
了解英国养老院SARS Co-V-2的感染和传播情况，为制定预防策略提供依据。在伦敦市中心受COVID-19疫情影响的4家养老院进行了一项涉及394名居民和70名工作人员的疫情调查。两个点的患病率调查进行了一个星期，其中居民进行了SARS-CoV-2检测，并记录了相关症状。四个家庭中有三个家庭的无症状工作人员也接受了SARS-CoV-2检测。总体而言，26%（95%CI 22-31）的居民在两个月内死亡。与前几年相比，全因死亡率增加了203%（95%CI 70-336）。系统检测发现40%（95%CI 35-46）的居民SARS-CoV-2呈阳性，其中43%（95%CI 34-52）无症状，18%（95%CI 11-24）仅出现非典型症状; 4%（95%CI-1至9）无症状工作人员的检测结果也呈阳性。在英国四家疗养院爆发的SARS-CoV-2与非常高的感染率和死亡率有关。许多居民出现非典型或没有明显症状。一些无症状的工作人员的检测结果也呈阳性，这表明对居民和工作人员进行定期筛查在减轻未来疫情方面的作用。
To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents. An outbreak investigation involving 394 residents and 70 staff, was carried out in 4 nursing homes affected by COVID-19 outbreaks in central London. Two point-prevalence surveys were performed one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing. Overall, 26% (95% CI 22–31) of residents died over the two-month period. All-cause mortality increased by 203% (95% CI 70–336) compared with previous years. Systematic testing identified 40% (95% CI 35–46) of residents as positive for SARS-CoV-2, and of these 43% (95% CI 34–52) were asymptomatic and 18% (95% CI 11–24) had only atypical symptoms; 4% (95% CI −1 to 9) of asymptomatic staff also tested positive. The SARS-CoV-2 outbreak in four UK nursing homes was associated with very high infection and mortality rates. Many residents developed either atypical or had no discernible symptoms. A number of asymptomatic staff members also tested positive, suggesting a role for regular screening of both residents and staff in mitigating future outbreaks.
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