Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation.
Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation.
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DOI：
10.1155/2021/4061525
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发表时间：
2021
影响因子：
--
通讯作者：
Ma M
中科院分区：
文献类型：
--
作者：
Yu B;Yu X;Xiong J;Ma M
转移是癌症相关死亡的主要原因。从分子水平上了解肿瘤转移的发病机制对肿瘤研究具有重要意义。然而，对肿瘤转移的分子诊断或治疗是有限的。越来越多的证据表明，表观遗传改变存在于所有人类癌症中，表观遗传调控是促进肿瘤转移不可或缺的因素。随着研究的深入和技术的进步，表观遗传调控的功能和机制日益清晰，包括DNA甲基化、组蛋白/RNA修饰、前体信使RNA选择性剪接和非编码RNA。目前，表观遗传疗法在肿瘤治疗中的应用正成为一条可行的治疗路线。在这篇综述中，我们寻找了表观遗传调控的关键分子，并讨论了它们在肿瘤转移中的相关调控机制。此外，我们强调了有前景的治疗策略，包括为诊断目的监测血清DNA，以及针对DNA和组蛋白甲基化的早期临床试验治疗。这也可能有助于寻找新的靶点，以进一步预测和诊断癌症转移。
Metastasis is the leading cause of cancer-related deaths. Understanding the pathogenesis of metastasis at the molecular levels is of great significance for cancer research. However, the molecular diagnosis or treatment of cancer metastasis is limited. Accumulating and growing evidence shows that epigenetic changes are present in all human cancers, and epigenetic regulation is an indispensable factor to promote tumor metastasis. With the deepening of research and the advancement of technology, the function and mechanism of epigenetic regulation, including DNA methylation, histone/RNA modification, and precursor messenger RNA alternative splicing and noncoding RNAs, has become more increasingly clear. At present, the application of epigenetic therapies in tumor treatment is becoming a feasible therapeutic route. In this review, we looked for the key molecules in epigenetic regulation and discuss their relative regulating mechanisms in cancer metastasis. Furthermore, we highlight promising therapeutic strategies, including monitoring serum DNA for diagnostic purposes and early phase clinical trial therapies that target DNA and histone methylation. This may also be beneficial in finding new targets for further prognosis and diagnosis of cancer metastasis.
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DOI：
10.1038/nrm.2017.27
发表时间：
2017-07
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Baralle FE;Giudice J
通讯作者：
Giudice J
影响因子：
48
作者：
Angermueller C;Clark SJ;Lee HJ;Macaulay IC;Teng MJ;Hu TX;Krueger F;Smallwood S;Ponting CP;Voet T;Kelsey G;Stegle O;Reik W
通讯作者：
Reik W
circTP63 作为 ceRNA 通过上调 FOXM1 促进肺鳞状细胞癌进展
影响因子：
16.6
作者：
Cheng, Zhuoan;Yu, Chengtao;Qin, Wenxin
通讯作者：
Qin, Wenxin
影响因子：
11.5
作者：
de Cubas, Aguirre A.;Korpershoek, Esther;Robledo, Mercedes
通讯作者：
Robledo, Mercedes
影响因子：
23.9
作者：
Cuiffo, Benjamin G.;Campagne, Antoine;Kamoub, Antoine E.
通讯作者：
Kamoub, Antoine E.