Altered Effective Connectivity of Central Autonomic Network in Response to Negative Facial Expression in Adults With Cannabis Use Disorder.
Altered Effective Connectivity of Central Autonomic Network in Response to Negative Facial Expression in Adults With Cannabis Use Disorder.
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DOI：
10.1016/j.bpsc.2019.05.013
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Moeller FG
中科院分区：
文献类型：
--
作者：
Ma L;Steinberg JL;Bjork JM;Wang Q;Hettema JM;Abbate A;Moeller FG
大麻的使用与压力相关的不良心血管事件的风险增加有关。由于中枢自主神经网络（CAN）的大脑区域在很大程度上与情绪和压力神经反应相关的大脑区域重叠，CAN可能介导对消极情绪刺激的自主神经反应。我们的目的是获得大麻使用障碍（CUD）患者暴露于负面情绪刺激时CAN的神经连通性是否改变的证据。利用动态因果模型对23名CUD受试者和23名人类连接组项目的对照组进行功能性磁共振成像数据进行了有效（定向）连接（EC）分析，这些数据来自于他们在执行一项带有负面面孔（恐惧/愤怒）和中性形状刺激的情绪面孔匹配任务时获得的数据。在消极面孔试验期间，相对于中性形状试验，测量了EC差异（调节变化）。CUD组在非成像测量和脑激活方面与对照组相似，但左侧杏仁核对下丘脑EC的调节变化更大（与感知应激评分呈正相关），右侧杏仁核对双侧梭状回EC的调节变化（与感知应激评分呈正相关），左侧腹外侧前额叶皮层对双侧梭状回EC的调节变化（与感知应激评分负相关）。左杏仁核到下丘脑的皮层和右杏仁核到双侧梭状回的皮层可能是导致CUD个体出现压力相关疾病风险的电路的一部分。相应地，左腹外侧前额叶皮层到双侧梭状回的ECs可能是反映保护机制的回路的一部分。
Cannabis use is associated with an increased risk of stress-related adverse cardiovascular events. Because brain regions of the central autonomic network (CAN) largely overlap with brain regions related to the neural response to emotion and stress, the CAN may mediate the autonomic response to negative emotional stimuli. We aimed to obtain evidence whether neural connectivity of the CAN is altered in individuals with cannabis use disorder (CUD) when they are exposed to negative emotional stimuli. Effective (directional) connectivity (EC) analysis using Dynamic Causal Modeling was applied to functional magnetic resonance imaging data acquired from 23 CUD subjects and 23 controls of the Human Connectome Project while they performed an emotional face-matching task with interleaving periods of negative-face (fearful/angry) and neutral-shape stimuli. The EC difference (modulatory change) was measured during the negative-face trials relative to the neutral-shape trials. The CUD group was similar to the controls in non-imaging measures and brain activations, but showed greater modulatory changes in the left amygdala to hypothalamus EC (positively associated with Perceived-Stress score), the right amygdala to bilateral fusiform gyri ECs (positively associated with Perceived-Stress score), and the left ventrolateral prefrontal cortex to bilateral fusiform gyri ECs (negatively associated with Perceived-Stress score). The left amygdala to hypothalamus EC and the right amygdala to bilateral fusiform gyri ECs are possibly part of circuits underlying the risk of CUD individuals to stress-related disorders. Correspondingly, the left ventrolateral prefrontal cortex to bilateral fusiform gyri ECs are possibly part of circuits reflecting a protective mechanism.
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影响因子：
5.7
作者：
Buchel, C;Holmes, AP;Friston, KJ
通讯作者：
Friston, KJ
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
可卡因和大麻在具有心肌梗塞的年轻人中使用。
影响因子：
24
作者：
DeFilippis EM;Singh A;Divakaran S;Gupta A;Collins BL;Biery D;Qamar A;Fatima A;Ramsis M;Pipilas D;Rajabi R;Eng M;Hainer J;Klein J;Januzzi JL;Nasir K;Di Carli MF;Bhatt DL;Blankstein R
通讯作者：
Blankstein R
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
2.1
作者：
Christensen TE;Bang LE;Holmvang L;Hasbak P;Kjær A;Bech P;Østergaard SD
通讯作者：
Østergaard SD