Effects of a glucagon-like peptide-1 analog on appetitive and consummatory behavior for rewarding and aversive gustatory stimuli in rats.
Effects of a glucagon-like peptide-1 analog on appetitive and consummatory behavior for rewarding and aversive gustatory stimuli in rats.
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DOI：
10.1016/j.physbeh.2020.113279
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发表时间：
2021-02-01
影响因子：
2.9
通讯作者：
Grigson PS
中科院分区：
文献类型：
--
作者：
Douton JE;Norgren R;Grigson PS
胰升糖素样肽-1(GLP-1)是一种胰岛素样激素，对调节食物摄入量是必不可少的，被批准用于治疗人类2型糖尿病和肥胖症。最近，GLP-1因其调节食物和药物的动机的能力而受到调查。奖励行为可以分为两个部分：“动机”(即接近和消费行为)和“情感”(即感知的适口性)。研究表明，GLP-1类似物降低了接近和消费美味食物的动机，但对情感反应的影响尚不清楚。因此，本研究测试了GLP-1类似物Exendin-4(Ex-4)对口服蔗糖和奎宁的食欲反应的影响。结果表明，Ex-4(2.4ug/kg ip)不能改变小鼠对蔗糖的被动滴水、食欲反应(即嘴巴运动、舌头突出和舌侧突出)或厌恶反应(即张口)。然而，舔爪子的情况大大减少了Ex-4。Ex-4处理对奎宁的被动滴注也没有影响，但延长了张口潜伏期，减少了张口总数。此外，Ex-4减少了限水大鼠奎宁的摄入量，但不能减少条件厌恶(即张口)或避免(即减少摄入量)LiCl配对糖精线索。因此，虽然Ex-4对习得的厌恶没有影响，但它减少了对甜味和苦味溶液的接近和摄取，同时几乎保持了对甜味的食欲情感反应，对苦味的厌恶情感反应减少。然后，使用Ex-4治疗，根据刺激的价态以及它的价态是后天获得的还是与生俱来的，不同地调节奖励的食欲和消耗性成分。
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that is essential for the regulation of food intake and approved for the treatment of type 2 diabetes mellitus and obesity in humans. More recently, GLP-1 has been investigated for its ability to modulate motivation for food and drugs. Reward behavior can be divided into two components: ‘motivational’ (i.e., approach and consummatory behaviors) and ‘affective’ (i.e., perceived palatability). Studies show that GLP-1 analogs reduce the motivation to approach and consume palatable food, but the impact on affective responding is unknown. Thus, the present study tested the effect of the GLP-1 analog, Exendin-4 (Ex-4), on the appetitive response to intraorally delivered sucrose and quinine. Results showed that Ex-4 (2.4ug/kg ip) failed to alter passive drip, appetitive reactions (i.e., mouth movements, tongue protrusions, and lateral tongue protrusions) or aversive reactions (i.e., gapes) to sucrose. Paw-licking, however, was significantly reduced by Ex-4. Treatment with Ex-4 also failed to influence passive drip to quinine, but increased the latency to gape and reduced the total number of gapes emitted. In addition, Ex-4 reduced intake of quinine in water restricted rats, but did not reduce conditioned aversion (i.e., gapes) or avoidance (i.e., reduced intake) of a LiCl-paired saccharin cue. Thus, while Ex-4 had no effect on a learned aversion, it reduced approach and ingestion of sweet and bitter solutions, while leaving the appetitive affective response to the sweet almost intact, and the aversive affective response to the bitter reduced. Treatment with Ex-4, then, differentially modulates appetitive and consummatory components of reward, depending on the valence of the stimulus and whether its valence is learned or innate.
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DOI：
10.1037/h0036962
发表时间：
1974-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARKER, LM;SMITH, JC
通讯作者：
SMITH, JC
DOI：
10.1152/ajpregu.00179.2014
发表时间：
2014-08-15
影响因子：
2.8
作者：
Alhadeff, Amber L.;Grill, Harvey J.
通讯作者：
Grill, Harvey J.
影响因子：
4.7
作者：
Kanoski SE;Rupprecht LE;Fortin SM;De Jonghe BC;Hayes MR
通讯作者：
Hayes MR
影响因子：
1.9
作者：
Colechio, Elizabeth M.;Imperio, Caesar G.;Grigson, Patricia S.
通讯作者：
Grigson, Patricia S.
影响因子：
2.9
作者：
Abbott, CR;Monteiro, M;Bloom, SR
通讯作者：
Bloom, SR