Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization.
Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization.
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DOI：
10.1155/2013/257381
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发表时间：
2013
影响因子：
1.9
通讯作者：
Nishida K
中科院分区：
文献类型：
--
作者：
Wakabayashi T;Ikuno Y;Oshima Y;Hamasaki T;Nishida K
目的.目的探讨近视性脉络膜新生血管（CNV）患者眼房水中血管内皮生长因子（VEGF）的含量。方法.收集16例（16眼）活动性近视CNV患者、16例（23眼）无近视CNV患者和7例（8眼）对照眼的房水样本，采用酶联免疫吸附法测定VEGF浓度。比较各组VEGF浓度的差异。结果与对照组（116.6 pg/mL）相比，近视CNV组（82.0 pg/mL）（P = 0.016）和高度近视无近视CNV组（58.9 pg/mL）（P < 0.001）的平均VEGF浓度显著降低。高度近视眼中有近视CNV者VEGF浓度显著高于无近视CNV者（P < 0.05）。在高度近视伴或不伴CNV的眼中，VEGF浓度与近视CNV的存在显著相关（逐步回归分析，R = 0.325，P = 0.044），但与年龄、眼轴长度或眼压无关。结论VEGF水平升高可能在高度近视眼CNV的发病机制中起作用。
Purpose. To investigate aqueous concentrations of vascular endothelial growth factor (VEGF) in eyes with myopic choroidal neovascularization (CNV). Methods. Aqueous samples were collected, and VEGF concentrations were measured by enzyme-linked immunosorbent assay in 16 eyes (16 patients) with active myopic CNV, 23 eyes (16 patients) with high myopia without myopic CNV, and 8 control eyes (7 patients). Differences in the concentrations of VEGF in each group were compared. Results. The estimated mean VEGF concentrations were significantly lower in eyes with myopic CNV (82.0 pg/mL) (P = 0.016 ) and with high myopia without myopic CNV (58.9 pg/mL) (P < 0.001) compared with controls (116.6 pg/mL). The estimated mean VEGF concentration was significantly (P < 0.05) higher in eyes with myopic CNV than in those without myopic CNV in highly myopic eyes. In eyes with high myopia with and without CNV, the VEGF concentration was significantly (stepwise regression analysis, R = 0.325, P = 0.044) associated with the presence of myopic CNV but not with age, axial length, or intraocular pressure. Conclusion. Increased levels of VEGF may play a role in the pathogenesis of CNV in highly myopic eyes.
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影响因子：
4.1
作者：
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通讯作者：
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