Low expression of acyl-CoA thioesterase 13 is associated with poor prognosis in ovarian serous cystadenocarcinoma.
Low expression of acyl-CoA thioesterase 13 is associated with poor prognosis in ovarian serous cystadenocarcinoma.
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DOI：
10.3389/fgene.2023.1213022
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发表时间：
2023
影响因子：
3.7
通讯作者：
Wang, Changyu
中科院分区：
文献类型：
--
作者：
Lv, Xiaofeng;Wang, Weijiao;Liu, Xiaoyu;Liu, Yuhuan;Guo, Lili;Wang, Changyu
目的：酰基辅酶A硫酯酶13（ACOT 13）是硫酯酶超家族的一员。在卵巢癌中未见报道。本研究旨在探讨ACOT 13在卵巢浆液性囊腺癌（OSC）中的表达及其预后价值。 研究方法：我们提取并分析了TCGA、GEPIA、THPA、GTEx、miRWalk和GDSC数据库，以研究ACOT 13在OSC中的潜在致癌机制，包括ACOT 13与预后、免疫检查点、肿瘤突变负荷（TMB）和50%抑制浓度（IC 50）评分的相关性。采用Kaplan-Meier生存分析比较终点事件的发生率。用单因素和多因素考克斯回归分析评价影响OSC预后的独立因素，并建立列线图。 结果如下：ACOT 13在骨肉瘤中的表达与肿瘤分期有关，Ⅰ、Ⅱ期的表达高于Ⅲ、Ⅳ期。此外，观察到ACOT 13的低表达与患有OSC的患者的不良总生存期（OS）、无进展生存期（PFS）和疾病特异性生存期（DSS）相关。ACOT 13表达与免疫检查点唾液酸结合Ig样凝集素（SIGLEC）15和TMB呈正相关。ACOT 13低表达的患者具有较高的顺铂IC 50评分。 结论：ACOT 13是一个独立的预后因子，是一个有希望的临床靶点。今后，ACOT 13在卵巢癌中的致癌机制和临床应用价值有待进一步研究。
Objective: Acyl-CoA thioesterase 13 (ACOT13) encodes a member of the thioesterase superfamily. It has not been reported in ovarian cancer. This research aimed at evaluating the expression and prognostic value of ACOT13 in ovarian serous cystadenocarcinoma (OSC). Methods: We extracted and analyzed TCGA, GEPIA, THPA, GTEx, miRWalk, and GDSC databases to investigate the potential carcinogenic mechanism of ACOT13 in OSC, including the correlation of ACOT13 with prognosis, immune checkpoint, tumor mutational burden (TMB), and 50% inhibition concentration (IC50) score. The incidence of endpoint events was compared with Kaplan-Meier survival analysis. Independent prognostic factors for OSC were evaluated with univariate and multivariate Cox regression analyses, and a nomogram was established. Results: The expression of ACOT13 was increased in OSC and correlated with tumor stage, with higher expression in stages I and II than in stages III and IV. Besides, it was observed that low expression of ACOT13 is correlated with poor overall survival (OS), progression-free survival (PFS), and disease-specific survival (DSS) in patients with OSC. There was a positive correlation between ACOT13 expression and immune checkpoint sialic acid-binding Ig-like lectin (SIGLEC) 15 and TMB. Patients with low ACOT13 expression had higher cisplatin IC50 scores. Conclusion: ACOT13 is an independent prognostic factor and a promising clinical target for OSC. In the future, the carcinogenic mechanism and clinical application value of ACOT13 in ovarian cancer need to be further studied.
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