Neural correlates of coherent and biological motion perception in autism.
Neural correlates of coherent and biological motion perception in autism.
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DOI：
10.1111/j.1467-7687.2011.01058.x
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发表时间：
2011-09
影响因子：
3.7
通讯作者：
Rivera SM
中科院分区：
文献类型：
--
作者：
Koldewyn K;Whitney D;Rivera SM
最近的证据表明，自闭症患者的视觉运动知觉可能普遍受损。为了检验这一点，我们调查了连贯性和生物运动处理的青少年自闭症采用心理物理和功能磁共振成像方法。那些自闭症患者在连贯运动感知方面表现得与对照组一样好，但生物运动感知的阈值明显更高。自闭症组在生物运动任务期间显示出减少的后上级颞沟（pSTS）、顶叶和额叶活动，而在连贯性和生物运动试验期间显示出类似的MT+/V5活动水平。MT+/V5的活动可预测两组的个体相干运动阈值。在对照组中，背外侧前额叶皮层（DLPFC）和pSTS的活动可以预测生物运动阈值，但在自闭症患者中则不然。然而，值得注意的是，DLPFC的活动与自闭症症状的严重程度呈负相关。这些结果表明，高阶社会或注意力网络的损伤可能是自闭症中观察到的视觉运动缺陷的基础。
Recent evidence suggests those with autism may be generally impaired in visual motion perception. To examine this, we investigated both coherent and biological motion processing in adolescents with autism employing both psychophysical and fMRI methods. Those with autism performed as well as matched controls during coherent motion perception but had significantly higher thresholds for biological motion perception. The autism group showed reduced posterior Superior Temporal Sulcus (pSTS), parietal and frontal activity during a biological motion task while showing similar levels of activity in MT+/V5 during both coherent and biological motion trials. Activity in MT+/V5 was predictive of individual coherent motion thresholds in both groups. Activity in dorsolateral prefrontal cortex (DLPFC) and pSTS was predictive of biological motion thresholds in control participants but not in those with autism. Notably, however, activity in DLPFC was negatively related to autism symptom severity. These results suggest that impairments in higher-order social or attentional networks may underlie visual motion deficits observed in autism.
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影响因子：
2.6
作者：
Cowey, A;Vaina, LM
通讯作者：
Vaina, LM
影响因子：
2.5
作者：
Herrington, John D.;Baron-Cohen, Simon;Williams, Steve C. R.
通讯作者：
Williams, Steve C. R.
影响因子：
1.8
作者：
Grossman, ED;Blake, R
通讯作者：
Blake, R
影响因子：
3.9
作者：
Hubert, B.;Wicker, B.;Deruelle, C.
通讯作者：
Deruelle, C.
影响因子：
3.4
作者：
Cavanagh, P;Labianca, AT;Thornton, IM
通讯作者：
Thornton, IM