Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity.
Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity.
复制标题
DOI：
10.4049/jimmunol.1101248
复制
发表时间：
2011-08-15
期刊：
影响因子：
--
通讯作者：
Barouch DH
中科院分区：
文献类型：
--
作者：
Kaufman DR;De Calisto J;Simmons NL;Cruz AN;Villablanca EJ;Mora JR;Barouch DH
维生素A缺乏症在许多发展中国家非常普遍，疫苗接种计划对公共卫生至关重要。然而，维生素A缺乏对疫苗免疫原性和保护效力的影响以前尚未确定。在这里，我们表明，维生素A代谢物视黄酸是至关重要的运输疫苗诱导的T淋巴细胞的胃肠道粘膜和疫苗的保护效力在小鼠。中度维生素A缺乏废除抗原特异性T淋巴细胞运输到胃肠道，胃肠道细胞免疫反应，并保护粘膜的挑战后，用重组腺病毒（rAd）疫苗载体免疫。口服维生素A补充剂以及维甲酸管理完全恢复粘膜免疫应答和疫苗保护效力。这些数据表明，口服维生素A补充剂可能是重要的，以优化艾滋病毒-1和其他粘膜病原体的疫苗在发展中国家的成功，强调宿主营养状况和疫苗的疗效之间的关键关系。
Vitamin A deficiency is highly prevalent in much of the developing world, where vaccination programs are of paramount importance to public health. However, the impact of vitamin A deficiency on the immunogenicity and protective efficacy of vaccines has not previously been defined. Here we show that the vitamin A metabolite retinoic acid is critical for trafficking of vaccine-elicited T-lymphocytes to the gastrointestinal mucosa and for vaccine protective efficacy in mice. Moderate vitamin A deficiency abrogated antigen-specific T-lymphocyte trafficking to the gastrointestinal tract, gastrointestinal cellular immune responses, and protection against a mucosal challenge following immunization with a recombinant adenovirus (rAd) vaccine vector. Oral vitamin A supplementation as well as retinoic acid administration fully restored the mucosal immune responses and vaccine protective efficacy. These data suggest that oral vitamin A supplementation may be important for optimizing the success of vaccines against HIV-1 and other mucosal pathogens in the developing world, highlighting a critical relationship between host nutritional status and vaccine efficacy.
登录
查看更多内容
影响因子：
4.5
作者：
Imdad A;Yakoob MY;Sudfeld C;Haider BA;Black RE;Bhutta ZA
通讯作者：
Bhutta ZA
影响因子：
158.5
作者：
Michaëlsson, K;Lithell, H;Melhus, H
通讯作者：
Melhus, H
影响因子：
4.3
作者：
Bhaskaram, P.;Rao, K. Visweswara
通讯作者：
Rao, K. Visweswara
影响因子：
6.4
作者：
DeCicco, KL;Zolfaghari, R;Ross, AC
通讯作者：
Ross, AC
影响因子：
4.4
作者：
Barouch, DH;Pau, MG;Goudsmit, J
通讯作者：
Goudsmit, J