Hypericum japonicum Thunb. ex Murray: phytochemistry, pharmacology, quality control and pharmacokinetics of an important herbal medicine.

Hypericum japonicum Thunb. ex Murray: phytochemistry, pharmacology, quality control and pharmacokinetics of an important herbal medicine.
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DOI:
10.3390/molecules190810733
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发表时间:
2014-07-24
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
He JY
He JY
中科院分区:
其他
文献类型:
--
作者:
Liu LS;Liu MH;He JY

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田基黄墨累主要分布于亚洲、大洋洲和北美洲,是一种重要的草药。H.山茱萸含有许多有价值的次级代谢产物,如黄酮类化合物、间苯三酚和氧杂蒽酮,具有保肝、抗肿瘤、抗菌、抗病毒和抗氧化活性以及对心血管系统和免疫的作用。结合植物化学和药理学研究,已经开发了一系列的分析方法来评价H。以其生物活性成分为基础,药代动力学研究涉及两个主要黄酮类化合物的吸收H。日本血吸虫感染。本文就其植物化学、药理学、质量控制及药代动力学等方面的研究进展作一综述。japonicum,这将有助于H.本发明的目的在于开发用于多种疾病的新药和治疗剂。
Hypericum japonicum Thunb. ex Murray is mainly distributed throughout Asia, Oceania and North America and is used as an important herbal medicine. H. japonicum contains many valuable secondary metabolites, such as flavonoids, phloroglucinols and xanthones and has hepatoprotective, anti-tumor, antibacterial, antiviral, and antioxidant activities and effects on the cardiovascular system and immunity. Coupled with phytochemical and pharmacological research, a series of analytical methods have been developed to evaluate the quality of H. japonicum based on its bioactive components. A pharmacokinetics study involved the absorption of two main flavonoids of H. japonicum in rats. This review aims to present an up-to-date and comprehensive overview of the phytochemistry, pharmacology, quality control and pharmacokinetics of H. japonicum, which should be useful for the greater development of H. japonicum, especially in the development of new drugs and therapeutics for various diseases.
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