Aux/IAA Gene Family in Plants: Molecular Structure, Regulation, and Function.
Aux/IAA Gene Family in Plants: Molecular Structure, Regulation, and Function.
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植物中的 Aux/IAA 基因家族：分子结构、调控和功能
DOI：
10.3390/ijms19010259
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发表时间：
2018-01-16
影响因子：
5.6
通讯作者：
Zhang JZ
中科院分区：
文献类型：
--
作者：
Luo J;Zhou JJ;Zhang JZ
生长素在植物整个生命周期的多样化细胞和发育反应中发挥着至关重要的作用。植物可以快速感知并响应生长素水平的变化，这些反应涉及几类主要的生长素响应基因，包括生长素/吲哚-3-乙酸（Aux/IAA）家族、生长素响应因子（ARF）家族、生长素上调小RNA（SAUR）和生长素响应Gretchen Hagen3（GH3）家族。 Aux/IAA 蛋白是短寿命核蛋白，包含由生长素早期反应基因家族编码的几个高度保守的结构域。这些蛋白质具有与 ARF 相互作用并抑制 ARF 激活的基因转录的特定结构域。分子研究表明，Aux/IAA 家族成员可以与 ARF 形成不同的二聚体，以多种方式调节基因。 Aux/IAA 家族成员的功能分析表明，它们在植物发育中具有多种作用，例如根发育、芽生长和果实成熟。在这篇综述中，讨论了最近发现的有关 Aux/IAA 蛋白的分子特征、调控和蛋白质-蛋白质相互作用的细节。这些细节为植物发育过程中 Aux/IAA 蛋白功能的分子基础提供了新的见解。
Auxin plays a crucial role in the diverse cellular and developmental responses of plants across their lifespan. Plants can quickly sense and respond to changes in auxin levels, and these responses involve several major classes of auxin-responsive genes, including the Auxin/Indole-3-Acetic Acid (Aux/IAA) family, the auxin response factor (ARF) family, small auxin upregulated RNA (SAUR), and the auxin-responsive Gretchen Hagen3 (GH3) family. Aux/IAA proteins are short-lived nuclear proteins comprising several highly conserved domains that are encoded by the auxin early response gene family. These proteins have specific domains that interact with ARFs and inhibit the transcription of genes activated by ARFs. Molecular studies have revealed that Aux/IAA family members can form diverse dimers with ARFs to regulate genes in various ways. Functional analyses of Aux/IAA family members have indicated that they have various roles in plant development, such as root development, shoot growth, and fruit ripening. In this review, recently discovered details regarding the molecular characteristics, regulation, and protein–protein interactions of the Aux/IAA proteins are discussed. These details provide new insights into the molecular basis of the Aux/IAA protein functions in plant developmental processes.
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