Neural signatures of data-driven psychopathology dimensions at the transition to adolescence.
Neural signatures of data-driven psychopathology dimensions at the transition to adolescence.
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DOI：
10.1192/j.eurpsy.2021.2262
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发表时间：
2022-01-24
期刊：
影响因子：
--
通讯作者：
Frangou S
中科院分区：
文献类型：
--
作者：
Modabbernia A;Michelini G;Reichenberg A;Kotov R;Barch D;Frangou S
人类神经科学的挑战之一是揭示大脑组织和精神病理学之间的联系，以便更好地理解精神障碍的生物学基础。在这里，我们的目的是表征使用两种概念上不同的数据驱动的方法获得的精神病理学维度的神经相关性。通过独立成分分析（伊卡）和探索性因素分析（EFA）分别提取了最大程度可分离或相关的精神病理学维度，这些维度应用于参与青少年大脑认知发展研究的9至10岁儿童（n = 9983; 47.8%女性，50.8%白色）的儿童行为检查表项目。使用基于核的正则化最小二乘法确定与每个维度相关的脑形态测量、白色物质完整性和静息状态连接的模式，并使用斯皮尔曼相关系数在维度之间进行比较。伊卡确定了三个精神病理学维度，分别代表对立解除抑制、认知控制障碍和负面影响，具有明显的脑相关性。对立解除抑制与皮质表面积呈负相关，认知控制障碍与解剖和功能连接障碍呈负相关，而负面影响并未显示出与任何神经影像学测量的明显关联。全民教育确定了三个方面代表广泛的外部化，神经发育，和广泛的内部化问题与部分重叠的大脑相关。所有EFA衍生的尺寸与皮质表面积呈负相关，而功能和结构连接的措施只与神经发育方面。这项研究强调了皮质表面积和全球连接的重要性，在青春期前的精神病理学，并提供了证据分离的精神病理学维度与不同的大脑相关。
One of the challenges in human neuroscience is to uncover associations between brain organization and psychopathology in order to better understand the biological underpinnings of mental disorders. Here, we aimed to characterize the neural correlates of psychopathology dimensions obtained using two conceptually different data-driven approaches. Dimensions of psychopathology that were either maximally dissociable or correlated were respectively extracted by independent component analysis (ICA) and exploratory factor analysis (EFA) applied to the Childhood Behavior Checklist items from 9- to 10-year-olds (n = 9983; 47.8% female, 50.8% white) participating in the Adolescent Brain Cognitive Development study. The patterns of brain morphometry, white matter integrity and resting-state connectivity associated with each dimension were identified using kernel-based regularized least squares and compared between dimensions using Spearman’s correlation coefficient. ICA identified three psychopathology dimensions, representing opposition–disinhibition, cognitive dyscontrol, and negative affect, with distinct brain correlates. Opposition–disinhibition was negatively associated with cortical surface area, cognitive dyscontrol was negatively associated with anatomical and functional dysconnectivity while negative affect did not show discernable associations with any neuroimaging measure. EFA identified three dimensions representing broad externalizing, neurodevelopmental, and broad Internalizing problems with partially overlapping brain correlates. All EFA-derived dimensions were negatively associated with cortical surface area, whereas measures of functional and structural connectivity were associated only with the neurodevelopmental dimension. This study highlights the importance of cortical surface area and global connectivity for psychopathology in preadolescents and provides evidence for dissociable psychopathology dimensions with distinct brain correlates.
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影响因子：
1.3
作者：
Achenbach, T M;Ruffle, T M
通讯作者：
Ruffle, T M
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
4.4
作者：
Kairov U;Cantini L;Greco A;Molkenov A;Czerwinska U;Barillot E;Zinovyev A
通讯作者：
Zinovyev A
影响因子：
4.8
作者：
Frangou S;Modabbernia A;Williams SCR;Papachristou E;Doucet GE;Agartz I;Aghajani M;Akudjedu TN;Albajes-Eizagirre A;Alnaes D;Alpert KI;Andersson M;Andreasen NC;Andreassen OA;Asherson P;Banaschewski T;Bargallo N;Baumeister S;Baur-Streubel R;Bertolino A;Bonvino A;Boomsma DI;Borgwardt S;Bourque J;Brandeis D;Breier A;Brodaty H;Brouwer RM;Buitelaar JK;Busatto GF;Buckner RL;Calhoun V;Canales-Rodríguez EJ;Cannon DM;Caseras X;Castellanos FX;Cervenka S;Chaim-Avancini TM;Ching CRK;Chubar V;Clark VP;Conrod P;Conzelmann A;Crespo-Facorro B;Crivello F;Crone EA;Dale AM;Dannlowski U;Davey C;de Geus EJC;de Haan L;de Zubicaray GI;den Braber A;Dickie EW;Di Giorgio A;Doan NT;Dørum ES;Ehrlich S;Erk S;Espeseth T;Fatouros-Bergman H;Fisher SE;Fouche JP;Franke B;Frodl T;Fuentes-Claramonte P;Glahn DC;Gotlib IH;Grabe HJ;Grimm O;Groenewold NA;Grotegerd D;Gruber O;Gruner P;Gur RE;Gur RC;Hahn T;Harrison BJ;Hartman CA;Hatton SN;Heinz A;Heslenfeld DJ;Hibar DP;Hickie IB;Ho BC;Hoekstra PJ;Hohmann S;Holmes AJ;Hoogman M;Hosten N;Howells FM;Hulshoff Pol HE;Huyser C;Jahanshad N;James A;Jernigan TL;Jiang J;Jönsson EG;Joska JA;Kahn R;Kalnin A;Kanai R;Klein M;Klyushnik TP;Koenders L;Koops S;Krämer B;Kuntsi J;Lagopoulos J;Lázaro L;Lebedeva I;Lee WH;Lesch KP;Lochner C;Machielsen MWJ;Maingault S;Martin NG;Martínez-Zalacaín I;Mataix-Cols D;Mazoyer B;McDonald C;McDonald BC;McIntosh AM;McMahon KL;McPhilemy G;Meinert S;Menchón JM;Medland SE;Meyer-Lindenberg A;Naaijen J;Najt P;Nakao T;Nordvik JE;Nyberg L;Oosterlaan J;de la Foz VO;Paloyelis Y;Pauli P;Pergola G;Pomarol-Clotet E;Portella MJ;Potkin SG;Radua J;Reif A;Rinker DA;Roffman JL;Rosa PGP;Sacchet MD;Sachdev PS;Salvador R;Sánchez-Juan P;Sarró S;Satterthwaite TD;Saykin AJ;Serpa MH;Schmaal L;Schnell K;Schumann G;Sim K;Smoller JW;Sommer I;Soriano-Mas C;Stein DJ;Strike LT;Swagerman SC;Tamnes CK;Temmingh HS;Thomopoulos SI;Tomyshev AS;Tordesillas-Gutiérrez D;Trollor JN;Turner JA;Uhlmann A;van den Heuvel OA;van den Meer D;van der Wee NJA;van Haren NEM;van 't Ent D;van Erp TGM;Veer IM;Veltman DJ;Voineskos A;Völzke H;Walter H;Walton E;Wang L;Wang Y;Wassink TH;Weber B;Wen W;West JD;Westlye LT;Whalley H;Wierenga LM;Wittfeld K;Wolf DH;Worker A;Wright MJ;Yang K;Yoncheva Y;Zanetti MV;Ziegler GC;Karolinska Schizophrenia Project (KaSP);Thompson PM;Dima D
通讯作者：
Dima D
影响因子：
6.9
作者：
Erskine HE;Moffitt TE;Copeland WE;Costello EJ;Ferrari AJ;Patton G;Degenhardt L;Vos T;Whiteford HA;Scott JG
通讯作者：
Scott JG