De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface.
De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface.
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从头设计的肽在石墨表面上形成了高度催化有序的纳米结构。
作者：
在这里，我们证明了短肽，从头设计的第一原则，自组装在石墨表面上产生一个非常强大的和催化的纳米结构，促进过氧化反应的活性，竞争对手的天然酶在单一和多底物反应。这些可设计的肽概括了底层石墨表面的对称性，并以分级自组装方式作为电极上的血红素分子的分子支架。高度有序和均匀的混合石墨-肽-氯高铁血红素纳米结构显示出所报道的任何混合电极的最高法拉第效率。鉴于自组装肽材料促进的化学反应类型的爆炸性增长，这种产生复杂电催化组装体的新方法将产生高效且实际适用的电催化剂。 从头设计的肽在石墨表面上自组装，以产生高度稳健和活性的电催化剂，并促进过氧化反应，其活性可与天然酶在单一和多底物反应中的活性相媲美。
Here we demonstrate that short peptides, de novo designed from first principles, self-assemble on the surface of graphite to produce a highly robust and catalytic nanoarchitecture, which promotes peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. These designable peptides recapitulate the symmetry of the underlying graphite surface and act as molecular scaffolds to immobilize hemin molecules on the electrode in a hierarchical self-assembly manner. The highly ordered and uniform hybrid graphite–peptide–hemin nanoarchitecture shows the highest faradaic efficiency of any hybrid electrode reported. Given the explosive growth of the types of chemical reactions promoted by self-assembled peptide materials, this new approach to creating complex electrocatalytic assemblies will yield highly efficient and practically applicable electrocatalysts. De novo designed peptides self-assembled on a graphite surface to produce highly robust and active electrocatalysts and promote peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions.
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