Thrombo-inflammatory biomarkers and D-dimer in a biracial cohort study.
Thrombo-inflammatory biomarkers and D-dimer in a biracial cohort study.
复制标题
DOI：
10.1002/rth2.12632
复制
发表时间：
2021-12
影响因子：
4.6
通讯作者：
Cushman M
中科院分区：
文献类型：
--
作者：
Kamin Mukaz D;Gergi M;Koh I;Zakai NA;Judd SE;Sholzberg M;Baumann Kreuziger L;Freeman K;Colovos C;Olson NC;Cushman M
高D-二聚体是心血管疾病和静脉血栓栓塞症的危险因素。在普通人群中，D-二聚体和其他血栓炎症生物标志物在黑人中较高，与白人相比，黑人患这些疾病的风险也更高。评估黑人个体是否存在D-二聚体和血栓炎症生物标志物之间的夸大相关性，这些生物标志物是心血管疾病的特征。在一项横断面研究中，我们用线性回归的方法评估了11个血栓炎症生物标记物与D-二聚体的相关性。这项横断面研究涉及1068名卒中地理和种族差异的人群。大多数生物标志物的不良水平，特别是纤维蛋白原、因子、C反应蛋白、N末端前B型利钠肽和白介素6，与D-二聚体升高有关。与D-二聚体的几个关联因种族而显著不同。例如，与白人参与者相比，黑人参与者第八因子与D-二聚体的关联性是白人参与者的两倍多。具体地说，在黑人成年人中，D-二聚体每标准差(SD)高出因子VIII 26%，而在白人成年人中，D-二聚体仅比SD高出因子VIII高11%。在黑人而不是白人成年人中，较高的IL-10和可溶性CD14与较高的D-二聚体相关。研究结果表明，D-二聚体可能与心血管疾病和静脉血栓栓塞症的黑/白差异有关，因为它是黑人血栓炎症反应放大的标志。需要更好地了解普通人群中高D-二聚体的贡献者。
Higher D‐dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D‐dimer and other thrombo‐inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people. To assess whether Black individuals have an exaggerated correlation between D‐dimer and thrombo‐inflammatory biomarkers characteristic of cardiovascular diseases. Linear regression was used to assess correlations of 11 thrombo‐inflammatory biomarkers with D‐dimer in a cross‐sectional study of 1068 participants of the biracial Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Adverse levels of most biomarkers, especially fibrinogen, factor VIII, C‐reactive protein, N‐terminal pro‐B‐type natriuretic peptide, and interleukin (IL)‐6, were associated with higher D‐dimer. Several associations with D‐dimer differed significantly by race. For example, the association of factor VIII with D‐dimer was more than twice as large in Black compared to White participants. Specifically, D‐dimer was 26% higher per standard deviation (SD) higher factor VIII in Black adults and was only 11% higher per SD higher factor VIII in White adults. In Black but not White adults, higher IL‐10 and soluble CD14 were associated with higher D‐dimer. Findings suggest that D‐dimer might relate to Black/White differences in cardiovascular diseases and venous thromboembolism because it is a marker of amplified thrombo‐inflammatory response in Black people. Better understanding of contributors to higher D‐dimer in the general population is needed.
登录
查看更多内容
急性肾损伤对成人微小病变肾病凝血功能的影响
影响因子：
1.6
作者：
Huang MJ;Wei RB;Su TY;Wang Y;Li QP;Yang X;Lv XM;Chen XM
通讯作者：
Chen XM
DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
5.6
作者：
Goldwater, Deena;Karlamangla, Arun;Seeman, Teresa
通讯作者：
Seeman, Teresa
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
9.9
作者：
Jenny, Nancy Swords;Callas, Peter W.;Cushman, Mary
通讯作者：
Cushman, Mary