Glycosylated coumarins, flavonoids, lignans and phenylpropanoids from Wikstroemia nutans and their biological activities.
Glycosylated coumarins, flavonoids, lignans and phenylpropanoids from Wikstroemia nutans and their biological activities.
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DOI：
10.3762/bjoc.18.23
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发表时间：
2022
影响因子：
2.7
通讯作者：
Xue Y
中科院分区：
文献类型：
--
作者：
Wu M;Su X;Wu Y;Luo Y;Guo Y;Xue Y
垂穗千里光来自Benth.，对产于中国岭南地区的一种传统中草药-山茱萸进行了化学研究。本文报道了一个新的双香豆素糖苷化合物wikstrongly（1），沿着分离得到三个已知的双香豆素和三香豆素糖苷化合物（2-4），两个黄酮苷化合物（5-6）和十一个木脂素糖苷化合物（7-17）。nutans。结合1D和2D NMR，UV，IR，HRESIMS光谱数据以及化学转化，阐明了新结构，包括其绝对构型。化合物1-17为首次从植物W.其中化合物1-3、8和11为首次从挥发油属植物中报道。评价所有共分离物对脂多糖（LPS）诱导的小鼠RAW264.7巨噬细胞中一氧化氮（NO）产生的体外抑制作用。对所选化合物的抗菌活性进行了测试。丰富了该属植物次生代谢产物的结构多样性。
Wikstroemia nutans Champ. ex Benth., a traditional herbal medicine collected at the Lingnan region of China, was chemically investigated. A new biscoumarin glucoside, wikstronutin (1), along with three known bis- and tricoumarin glucosides (2–4), two flavonoid glycosides (5–6), and eleven lignan glucosides (7–17) were isolated from the stems and roots of W. nutans. The new structure including its absolute configuration was elucidated based on a combination of 1D and 2D NMR, UV, IR, HRESIMS spectroscopic data, as well as chemical transformation. Compounds 1–17 were first isolated from the plant species W. nutans, while compounds 1–3, 8, and 11 were reported from the genus Wikstroemia for the first time. All co-isolates were evaluated for their in vitro inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells. The antibacterial activity of the selected compounds was also tested. Our work enriches the structure diversity of the secondary metabolites from the genus Wikstroemia.
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DOI：
10.3390/molecules26226955
发表时间：
2021-11-18
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Su X;Wu Y;Wu M;Lu J;Jia S;He X;Liu S;Zhou Y;Xing H;Xue Y
通讯作者：
Xue Y
影响因子：
1.7
作者：
Iizuka, M;Warashina, T;Noro, T
通讯作者：
Noro, T
影响因子：
1.8
作者：
Liao, SG;Zhang, BL;Yue, JM
通讯作者：
Yue, JM
影响因子：
1.6
作者：
Hara, Hideaki;Ise, Yasuaki;Iinuma, Munekazu
通讯作者：
Iinuma, Munekazu
影响因子：
5.4
作者：
Zhang, Na;Shi, Zhengyi;Zhang, Yonghui
通讯作者：
Zhang, Yonghui