Preparation of porous chitosan-poly(acrylic acid)-calcium phosphate hybrid nanoparticles via mineralization
Preparation of porous chitosan-poly(acrylic acid)-calcium phosphate hybrid nanoparticles via mineralization
复制标题
矿化法制备多孔壳聚糖-聚丙烯酸-磷酸钙杂化纳米粒子
DOI：
10.1007/s11434-009-0259-3
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发表时间：
2009
影响因子：
--
通讯作者：
Xiqun Jiang
中科院分区：
文献类型：
--
作者：
Changjing Chen;Yu Deng;Eryun Yan;Yong Hu;Xiqun Jiang
本文报道了基于磷酸钙（CaP）在壳聚糖-聚丙烯酸纳米粒子（CS-PAA NPs）表面矿化的壳聚糖-聚丙烯酸-磷酸钙杂化纳米粒子（CS-PAA-CaP NP）的制备。CS-PAA-CaP纳米粒子是通过直接向CS-PAA纳米粒子的水溶液中加入氨或通过CS-PAA纳米粒子的水溶液中的尿素的热分解，导致CaP在CS-PAA纳米粒子表面上的矿化来实现的。通过这两种途径，特别是使用尿素作为pH调节剂，避免了在碱性环境中常见的CS-PAA NP沉淀。采用动态光散射（DLS）、透射电镜（TEM）、扫描电镜（SEM）、热重分析（TGA）和X射线衍射仪（XRD）对CS-PAA-CaP杂化纳米粒子的粒径、形貌和组成进行了表征。当尿素作为pH调节剂以促进尿素热分解过程中的矿化时，得到具有多孔结构的CaP壳和400-600 nm尺寸的规则CS-PAA-CaP杂化纳米颗粒。TGA结果显示，杂化纳米颗粒含有约23%的无机组分，这与起始材料的比例一致。混合纳米颗粒的XRD谱表明，磷酸氢钙（DCP：CaHPO 4）晶体是矿化的主要成分。CS-PAA-CaP杂化纳米颗粒的多孔结构可能在制药和其他医学应用中非常有用。
In this work, the preparation of chitosan-poly(acrylic acid)-calcium phosphate hybrid nanoparticles (CS-PAA-CaP NP) based on the mineralization of calcium phosphate (CaP) on the surface of chitosan-poly (acrylic acid) nanoparticles (CS-PAA NPs) was reported. CS-PAA-CaP NPs were achieved by directly adding ammonia to the aqueous solution of CS-PAA nanoparticles or by thermal decomposition of urea in the aqueous solution of CS-PAA nanoparticles, resulting in the mineralization of CaP on the surface of CS-PAA NPs. Through these two routes, especially using urea as a pH-regulator, the precipitation of CS-PAA NPs, a common occurrence in basic environment, was avoided. The size, morphology and ingredient of CS-PAA-CaP hybrid nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), scanning electron microscope (SEM), thermogravimetry analysis (TGA) and X-ray diffractometer (XRD). When urea was used as the pH regulator to facilitate the mineralization during the thermal urea decomposition procedure, regular CS-PAA-CaP hybrid nanoparticles with a porosity-structural CaP shells and 400–600 nm size were obtained. TGA result revealed that the hybrid NPs contained approximately 23% inorganic component, which was consistent with the ratio of starting materials. The XRD spectra of hybrid nanoparticles indicated that dicalcium phosphate (DCP: CaHPO4) crystal was a dominant component of mineralization. The porous structure of the CS-PAA-CaP hybrid NPs might be greatly useful in pharmaceutical and other medical applications.
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影响因子：
10.8
作者：
Perkin, KK;Turner, JL;Mann, S
通讯作者：
Mann, S
影响因子：
14
作者：
Grassmann, O;Löbmann, P
通讯作者：
Löbmann, P
影响因子：
9.5
作者：
Ehrlich, H;Krajewska, B;Worch, H
通讯作者：
Worch, H
影响因子：
10.8
作者：
Mao, HQ;Roy, K;Leong, KW
通讯作者：
Leong, KW