Choriocapillaris Changes Are Correlated With Disease Duration and MoCA Score in Early-Onset Dementia.
Choriocapillaris Changes Are Correlated With Disease Duration and MoCA Score in Early-Onset Dementia.
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早发性痴呆的脉络膜毛细血管变化与疾病持续时间和 MoCA 评分相关
DOI：
10.3389/fnagi.2021.656750
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发表时间：
2021
影响因子：
4.8
通讯作者：
Wu B
中科院分区：
文献类型：
--
作者：
Zhang S;Kwapong WR;Yang T;Liu P;Tuo Q;Cheng Y;Li X;Liu M;Lei P;Wu B
目的：脉络膜成像可以检测与早发性痴呆（EOD）相关的微血管变化，并且可以作为检测该疾病的指标。我们的目的是使用光学相干断层扫描血管造影 (OCTA) 分析 EOD 患者的体内脉络膜毛细血管 (CC) 血流密度，并评估其与临床测量的关联。方法：这项横断面研究使用 OCTA 对 25 名 EOD 患者和 20 名健康对照者的脉络膜毛细血管 (CC) 进行成像和分析。通过 OCT 工具中的内置算法测量 3 mm 区域和 6 mm 区域的脉络膜毛细血管血流密度。使用磁共振成像和认知评估进行脑容量并记录。结果：与健康对照相比，EOD 患者的脉络膜毛细血管毛细血管血流密度分别在 3.0 mm (P = 0.001) 和 6.0 mm (P < 0.001) 区域显着降低。 EOD 患者的蒙特利尔认知评估 (MoCA) 评分与 3 mm 区域的脉络膜毛细血管血流密度呈正相关（Rho = 0.466，P = 0.021）。 EOD患者的病程也与3 mm区域的脉络膜毛细血管密度呈负相关（Rho = -0.497，P = 0.008）。讨论：我们的报告表明，脉络膜毛细血管损伤可能是早发性痴呆的潜在指标。微血管损伤可能与痴呆的早期阶段有关，而衰老在其损伤中并未发挥作用。临床试验注册：www.ClinicalTrials.gov，ChiCTR2000041386。
Purpose: Imaging of the choroid may detect the microvascular changes associated with early-onset dementia (EOD) and may represent an indicator for detection of the disease. We aimed to analyze the in vivo choriocapillaris (CC) flow density in EOD patients using optical coherence tomography angiography (OCTA) and evaluate the association with its clinical measures. Methods: This cross-sectional study used the OCTA to image and analyze the choriocapillaris (CC) of 25 EOD patients and 20 healthy controls. Choriocapillaris flow density in the 3 mm area and 6 mm area was measured by an inbuilt algorithm in the OCT tool. Brain volume using magnetic resonance imaging and cognitive assessment was done and recorded. Results: Significantly reduced capillary flow density of the choriocapillaris was seen in EOD patients when compared to healthy controls in the 3.0 mm (P = 0.001) and 6.0 mm (P < 0.001) area respectively. Montreal Cognitive Assessment (MoCA) scores in EOD patients positively correlated with choriocapillaris flow density in the 3 mm area (Rho = 0.466, P = 0.021). Disease duration of EOD patients also negatively correlated with choriocapillaris density in the 3 mm area (Rho = −0.497, P = 0.008). Discussion: Our report suggests that choriocapillaris damage may be a potential indicator of early-onset dementia. Microvascular impairment may be involved in the early phase of dementia without aging playing a role in its impairment. Clinical Trial Registration: www.ClinicalTrials.gov, ChiCTR2000041386.
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影响因子：
5.7
作者：
Koronyo-Hamaoui, Maya;Koronyo, Yosef;Ljubimov, Alexander V.;Miller, Carol A.;Ko, MinHee K.;Black, Keith L.;Schwartz, Michal;Farkas, Daniel L.
通讯作者：
Farkas, Daniel L.
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
4.8
作者：
Laing KK;Simoes S;Baena-Caldas GP;Lao PJ;Kothiya M;Igwe KC;Chesebro AG;Houck AL;Pedraza L;Hernández AI;Li J;Zimmerman ME;Luchsinger JA;Barone FC;Moreno H;Brickman AM;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
34.7
作者：
Zlokovic, Berislav V.
通讯作者：
Zlokovic, Berislav V.
影响因子：
48
作者：
Rossor, Martin N.;Fox, Nick C.;Mummery, Catherine J.;Schott, Jonathan M.;Warren, Jason D.
通讯作者：
Warren, Jason D.