Cohort profile: Celiac disease genomic, environmental, microbiome and metabolome study; a prospective longitudinal birth cohort study of children at-risk for celiac disease.
Cohort profile: Celiac disease genomic, environmental, microbiome and metabolome study; a prospective longitudinal birth cohort study of children at-risk for celiac disease.
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队列谱：乳糜泻基因组，环境，微生物组和代谢组研究；对腹腔疾病的儿童对儿童的前瞻性纵向出生队列研究。
DOI：
10.1371/journal.pone.0282739
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
乳糜泻基因组、环境、微生物组和代谢研究(CDGEMM)是一项针对有乳糜泻(CD)风险的儿童的国际前瞻性出生队列研究。CDGEMM研究旨在采用多组学方法预测高危个体的CD发病。参与者被要求有一名有活检诊断为CD的一级家庭成员，并且必须在引入固体食物之前登记。参与包括在五年内纵向提供血液和粪便样本，以及回答与参与者、他们的家庭和环境有关的问卷。招聘和数据收集自2014年以来一直在进行。截至2022年，我们共有554名参与者，队列的平均年龄为56.4月。共有54名参与者的CD抗体呈阳性，31名患者确诊为CD。在54名CD患者中，大约80%的人在3岁时就发展成了CD。到目前为止，我们已经鉴定了几种微生物菌株、途径和代谢物，它们在CD发病前丰度增加并被检测到，以前被认为与自身免疫和炎症条件有关，而其他微生物在CD发病前丰度降低，已知具有抗炎作用。我们正在进行的分析包括扩展我们的代谢组学和代谢组学分析，评估与Cd发病有关的环境风险因素，以及调查微生物组和代谢物的变化如何防止或促进Cd发展的机制研究。
The Celiac Disease Genomic, Environmental, Microbiome and Metabolomic (CDGEMM) study is an international prospective birth cohort in children at-risk of developing celiac disease (CD). The CDGEMM study has been designed to take a multi-omic approach to predicting CD onset in at-risk individuals. Participants are required to have a first-degree family member with biopsy diagnosed CD and must be enrolled prior to the introduction of solid food. Participation involves providing blood and stool samples longitudinally over a period of five years as well as answering questionnaires related to the participant, their family, and environment. Recruitment and data collection have been ongoing since 2014. As of 2022 we have a total of 554 participants and the average age of the cohort is 56.4 months. A total of 54 participants have developed positive antibodies for CD and 31 have confirmed CD. Approximately 80% of the 54 participants with CD have developed it by 3 years of age. To date we have identified several microbial strains, pathways, and metabolites occurring in increased abundance and detected before CD onset, which have previously been linked to autoimmune and inflammatory conditions while others occurred in decreased abundance before CD onset and are known to have anti-inflammatory effects. Our ongoing analysis includes expanding our metagenomic and metabolomic analyses, evaluating environmental risk factors linked to CD onset, and mechanistic studies investigating how alterations in the microbiome and metabolites may protect against or contribute to CD development.
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影响因子：
158.5
作者：
Lionetti, Elena;Castellaneta, Stefania;Catassi, Carlo
通讯作者：
Catassi, Carlo
影响因子：
9.8
作者：
Marild, Karl;Kahrs, Christian R.;Stordal, Ketil
通讯作者：
Stordal, Ketil
影响因子：
--
作者：
Fasano, A;Berti, I;Horvath, K
通讯作者：
Horvath, K
影响因子：
5.9
作者：
Olshan KL;Zomorrodi AR;Pujolassos M;Troisi J;Khan N;Fanelli B;Kenyon V;Fasano A;Leonard MM
通讯作者：
Leonard MM
DOI：
10.1097/mpg.0000000000001532
发表时间：
2017-10
影响因子：
2.9
作者：
Almallouhi E;King KS;Patel B;Wi C;Juhn YJ;Murray JA;Absah I
通讯作者：
Absah I