Plant Glycosyltransferases Beyond CAZy: A Perspective on DUF Families.

Plant Glycosyltransferases Beyond CAZy: A Perspective on DUF Families.
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植物糖基转移酶超越了Cazy:对DUF家族的观点。

DOI:
10.3389/fpls.2012.00059
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发表时间:
2012
影响因子:
5.6
通讯作者:
Scheller HV
Scheller HV
中科院分区:
生物学2区
文献类型:
--
作者:
Hansen SF;Harholt J;Oikawa A;Scheller HV

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碳水化合物活性酶(CAZy)数据库是糖生物学的宝贵资源,目前包含45个在植物中代表的糖基转移酶家族。糖基转移酶(Glycosyltransferases,GTs)在植物中具有多种功能,但大多数可能参与植物细胞壁多糖和糖蛋白的生物合成。生物信息学方法和结构建模表明,植物中的许多蛋白质家族包括尚未被鉴定为GT的GT,因此不包括在CAZy中。这些家族包括具有未知功能结构域(DUF)的蛋白质DUF23、DUF246和DUF266。这些蛋白质是GT的证据和它们在细胞壁生物合成中可能的作用进行了讨论。
The carbohydrate active enzyme (CAZy) database is an invaluable resource for glycobiology and currently contains 45 glycosyltransferase families that are represented in plants. Glycosyltransferases (GTs) have many functions in plants, but the majority are likely to be involved in biosynthesis of polysaccharides and glycoproteins in the plant cell wall. Bioinformatic approaches and structural modeling suggest that a number of protein families in plants include GTs that have not yet been identified as such and are therefore not included in CAZy. These families include proteins with domain of unknown function (DUF) DUF23, DUF246, and DUF266. The evidence for these proteins being GTs and their possible roles in cell wall biosynthesis is discussed.
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