Heart Metabolism in Sepsis-Induced Cardiomyopathy-Unusual Metabolic Dysfunction of the Heart.
Heart Metabolism in Sepsis-Induced Cardiomyopathy-Unusual Metabolic Dysfunction of the Heart.
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DOI：
10.3390/ijerph18147598
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发表时间：
2021-07-16
影响因子：
--
通讯作者：
Zwolak A
中科院分区：
文献类型：
--
作者：
Wasyluk W;Nowicka-Stążka P;Zwolak A
由于需要持续工作，心脏消耗的能量占总能量消耗的8%。由于相对较低的三磷酸腺苷（ATP）储存能力，心脏的工作取决于其生产。这是可能的，因为心脏的代谢灵活性，使其能够使用许多底物作为能量来源。在正常条件下，健康的心脏通过线粒体中的氧化磷酸化获得大约95%的ATP。能量的主要来源是脂肪酸的氧化，其余的能量来自丙酮酸的氧化。心力衰竭的特征在于这些比例的紊乱，单个组分作为能量来源的贡献取决于心力衰竭的病因和阶段。心脏功能障碍的一种独特形式是脓毒症诱导的心肌病，其特征在于能量产生显著减少以及脂肪酸和葡萄糖的心脏氧化受损。代谢紊乱似乎有助于心功能不全的发病机制，因此是未来治疗的一个有前途的目标。然而，由于衰竭心脏代谢的许多方面仍然无法解释，这个问题需要进一步研究。
Due to the need for continuous work, the heart uses up to 8% of the total energy expenditure. Due to the relatively low adenosine triphosphate (ATP) storage capacity, the heart’s work is dependent on its production. This is possible due to the metabolic flexibility of the heart, which allows it to use numerous substrates as a source of energy. Under normal conditions, a healthy heart obtains approximately 95% of its ATP by oxidative phosphorylation in the mitochondria. The primary source of energy is fatty acid oxidation, the rest of the energy comes from the oxidation of pyruvate. A failed heart is characterised by a disturbance in these proportions, with the contribution of individual components as a source of energy depending on the aetiology and stage of heart failure. A unique form of cardiac dysfunction is sepsis-induced cardiomyopathy, characterised by a significant reduction in energy production and impairment of cardiac oxidation of both fatty acids and glucose. Metabolic disorders appear to contribute to the pathogenesis of cardiac dysfunction and therefore are a promising target for future therapies. However, as many aspects of the metabolism of the failing heart remain unexplained, this issue requires further research.
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DOI：
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发表时间：
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影响因子：
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