TCR-like biomolecules target peptide/MHC Class I complexes on the surface of infected and cancerous cells.
TCR-like biomolecules target peptide/MHC Class I complexes on the surface of infected and cancerous cells.
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DOI：
10.3109/08830185.2011.604880
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发表时间：
2011-10
影响因子：
5
通讯作者：
Hildebrand WH
中科院分区：
文献类型：
--
作者：
Weidanz JA;Hawkins O;Verma B;Hildebrand WH
人类白细胞抗原(HLA；也称为主要组织相容性，或MHC)I类系统提供区分健康细胞和疾病细胞的多肽。因此，多肽/MHC-I类标志物的发现可以为免疫治疗提供高度特异性的靶点。在近二十年的时间里，人们使用了各种策略来制造抗体，这些抗体对标记感染细胞和癌细胞的独特的多肽/MHC I类复合体具有识别特异性，但效果参差不齐。利用这些抗体试剂，新的多肽/MHC I类靶点已经在疾病细胞上被直接验证，并对抗原提呈的机制有了新的见解。最近，这些抗体在临床应用方面显示出了希望，例如针对癌症和感染细胞的治疗靶点，以及对疾病细胞的诊断和成像。在这篇综述中，我们全面介绍了用于识别疾病特异性多肽/MHC I类表位并产生这些标记的抗体的方法。最后，我们提供了几个例子来说明将这些抗体用作抗癌剂的前景。
The human leukocyte antigen (HLA; also called major histocompatibility, or MHC) class I system presents peptides that distinguish healthy from diseased cells. Therefore, the discovery of peptide/MHC class I markers can provide highly specific targets for immunotherapy. Over the course of almost two decades, various strategies have been used, with mixed success, to produce antibodies that have recognition specificity for unique peptide/MHC class I complexes that mark infected and cancerous cells. Using these antibody reagents, novel peptide/MHC class I targets have been directly validated on diseased cells and new insight has been gained into the mechanisms of antigen presentation. More recently, these antibodies have shown promise for clinical applications such as therapeutic targeting of cancerous and infected cells and diagnosis and imaging of diseased cells. In this review, we comprehensively describe the methods used to identify disease-specific peptide/MHC class I epitopes and generate antibodies to these markers. Finally, we offer several examples that illustrate the promise of using these antibodies as anti-cancer agents.
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影响因子：
56.9
作者：
Morgan, Richard A.;Dudley, Mark E.;Rosenberg, Steven A.
通讯作者：
Rosenberg, Steven A.
影响因子：
11.2
作者：
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DOI：
10.1073/pnas.93.5.1820
发表时间：
1996-03-05
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
2.1
作者：
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通讯作者：
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