Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment.
Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment.
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DOI：
10.1016/j.biopsych.2017.10.005
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发表时间：
2018-05-15
影响因子：
10.6
通讯作者：
Bale TL
中科院分区：
文献类型：
--
作者：
Chan JC;Nugent BM;Bale TL
父母的压力暴露与后代神经发育和神经精神疾病的风险有关，这促使人们对孕前和产前时期容易受到压力等环境损害的关键检查。来自人类研究和动物模型的证据表明，母亲和父亲的压力暴露在改变后代大脑发育过程中的影响。怀孕期间暴露代际传递模式的机制检查指出胎盘信号的改变，包括炎症、营养感应和表观遗传途径的改变。孕前父亲应激暴露的传播与精子表观遗传标记的变化有关，主要集中在DNA甲基化、组蛋白翻译后修饰和小非编码rna的重编程上。在这篇综述中，我们讨论了支持父母代际压力对后代神经发育和疾病风险的重要贡献的证据，以及目前已知的这种传递的表观遗传机制。
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and neuropsychiatric disorders, prompting critical examination of preconception and prenatal periods as vulnerable to environmental insults such as stress. Evidence from human studies and animal models demonstrates the influence that both maternal and paternal stress exposures have in changing the course of offspring brain development. Mechanistic examination of modes of intergenerational transmission of exposure during pregnancy has pointed to alterations in placental signaling, including changes in inflammatory, nutrient-sensing, and epigenetic pathways. Transmission of preconception paternal stress exposure is associated with changes in epigenetic marks in sperm, with a primary focus on the reprogramming of DNA methylation, histone post-translational modifications, and small non-coding RNAs. In this review, we discuss evidence supporting the important contribution of intergenerational parental stress in offspring neurodevelopment and disease risk, and the currently known epigenetic mechanisms underlying this transmission.
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