Inhibition of Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus by Positively Charged Silver Nanoparticles and Functionalized Silicone Elastomers.
Inhibition of Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus by Positively Charged Silver Nanoparticles and Functionalized Silicone Elastomers.
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DOI：
10.3390/pathogens9100784
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发表时间：
2020-09-25
期刊：
影响因子：
--
通讯作者：
Lopez-Ribot JL
中科院分区：
文献类型：
--
作者：
Lara HH;Lopez-Ribot JL
细菌和真菌生物体都显示出形成生物膜的能力;然而，混合的细菌/真菌生物膜特别难以控制和根除。机会性微生物病原体白色念珠菌和金黄色葡萄球菌是医疗保健获得性感染的最常见病原体之一，并且通常共同分离形成混合生物膜，特别是从污染的导管中分离。这些混合物种生物膜显示出高水平的抗生素耐药性;因此，这些感染具有治疗挑战性，导致过度的发病率和死亡率。在缺乏有效的常规抗生素治疗的情况下，基于纳米技术的方法代表了治疗高度顽固的多微生物生物膜感染的有希望的替代方案。我们的小组以前报道了一种新的微波技术合成的纯正电荷银纳米粒子对单一物种的生物膜的活性。albicans和S.金黄色。在这里，我们扩大了我们的观察，以证明银纳米粒子显示剂量依赖性的活性对双物种C。白色念珠菌/S.金黄色葡萄球菌生物膜此外，相同的纳米颗粒用于功能化导管材料，导致混合真菌/细菌生物膜的有效抑制。总的来说，我们的结果表明银纳米颗粒对这些跨界生物膜的有效活性。需要更多的研究来检查功能化导管在预防导管相关血流感染中的能力。
Both bacterial and fungal organisms display the ability to form biofilms; however, mixed bacterial/fungal biofilms are particularly difficult to control and eradicate. The opportunistic microbial pathogens Candida albicans and Staphylococcus aureus are among the most frequent causative agents of healthcare-acquired infections, and are often co-isolated forming mixed biofilms, especially from contaminated catheters. These mixed species biofilms display a high level of antibiotic resistance; thus, these infections are challenging to treat resulting in excess morbidity and mortality. In the absence of effective conventional antibiotic treatments, nanotechnology-based approaches represent a promising alternative for the treatment of highly recalcitrant polymicrobial biofilm infections. Our group has previously reported on the activity of pure positively charged silver nanoparticles synthesized by a novel microwave technique against single-species biofilms of C. albicans and S. aureus. Here, we have expanded our observations to demonstrate that that silver nanoparticles display dose-dependent activity against dual-species C. albicans/S. aureus biofilms. Moreover, the same nanoparticles were used to functionalize catheter materials, leading to the effective inhibition of the mixed fungal/bacterial biofilms. Overall, our results indicate the potent activity of silver nanoparticles against these cross-kingdom biofilms. More studies are warranted to examine the ability of functionalized catheters in the prevention of catheter-related bloodstream infections.
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影响因子：
3.7
作者：
Akers KS;Mende K;Cheatle KA;Zera WC;Yu X;Beckius ML;Aggarwal D;Li P;Sanchez CJ;Wenke JC;Weintrob AC;Tribble DR;Murray CK;Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group
通讯作者：
Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group
影响因子：
2
作者：
Altagracia Pimentel-Acosta, Citlalic;Neptali Morales-Serna, Francisco;Josefina Fajer-Avila, Emma
通讯作者：
Josefina Fajer-Avila, Emma
最新的纳米技术方法用于预防和治疗医疗设备上与生物膜相关的感染。
影响因子：
--
作者：
Ramasamy M;Lee J
通讯作者：
Lee J
影响因子：
1.6
作者：
Burnham JP;Rojek RP;Kollef MH
通讯作者：
Kollef MH
影响因子：
6.4
作者：
Kong EF;Tsui C;Kucharíková S;Andes D;Van Dijck P;Jabra-Rizk MA
通讯作者：
Jabra-Rizk MA