A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices.
A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices.
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DOI：
10.1016/j.biomaterials.2009.10.051
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发表时间：
2010-03
期刊：
影响因子：
14
通讯作者：
Jun, Ho-Wook
中科院分区：
文献类型：
--
作者：
Kushwaha, Meenakshi;Anderson, Joel M.;Bosworth, Charles A.;Andukuri, Adinarayana;Minor, William P.;Lancaster, Jack R., Jr.;Anderson, Peter G.;Brott, Brigitta C.;Jun, Ho-Wook
Cardiovascular disease is the number one cause of death in the United States. Deployment of stents and vascular grafts has been a major therapeutic method for treatment. However, restenosis, incomplete endothelialization, and thrombosis hamper the long term clinical success. As a solution to meet these current challenges, we have developed a native endothelial ECM mimicking self-assembled nanofibrous matrix to serve as a new treatment model. The nanofibrous matrix is formed by self-assembly of peptide amphiphiles (PAs), which contain nitric oxide (NO) donating residues, endothelial cell adhesive ligands composed of YIGSR peptide sequence, and enzyme-mediated degradable sites. NO was successfully released from the nanofibrous matrix rapidly within 48 hours, followed by sustained release over period of 30 days. The NO releasing nanofibrous matrix demonstrated a significantly enhanced proliferation of endothelial cells (51 ± 3 % to 67 ± 2 %) but reduced proliferation of smooth muscle cells (35 ± 2 % to 16 ± 3 %) after 48 hrs of incubation. There was also a 150-fold decrease in platelet attachment on the NO releasing nanofibrous matrix (470 ± 220 platelets/cm2) compared to the collagen-I (73 ± 22 × 103 platelets/cm2) coated surface. The nanofibrous matrix has the potential to be applied to various cardiovascular implants as a self-assembled coating, thereby providing a native endothelial extracellular matrix (ECM) mimicking environment.
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DOI：
10.1002/jbm.820250209
发表时间：
1991-02-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
MASSIA, SP;HUBBELL, JA
通讯作者：
HUBBELL, JA
DOI：
10.1152/ajpheart.1998.274.6.h2163
发表时间：
1998-06-01
影响因子：
4.8
作者：
Vaughn, MW;Kuo, L;Liao, JC
通讯作者：
Liao, JC
影响因子：
82.9
作者：
Aicher, A;Heeschen, C;Dimmeler, S
通讯作者：
Dimmeler, S
影响因子：
6.2
作者：
Jun, HW;Taite, LJ;West, JL
通讯作者：
West, JL
影响因子：
37.8
作者：
Finn, Aloke V.;Joner, Michael;Virmani, Renu
通讯作者：
Virmani, Renu