Altered methylation in tandem repeat element and elemental component levels in inhalable air particles.
Altered methylation in tandem repeat element and elemental component levels in inhalable air particles.
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DOI：
10.1002/em.21829
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发表时间：
2014-04
影响因子：
2.8
通讯作者：
Baccarelli, Andrea A.
中科院分区：
文献类型：
--
作者：
Hou, Lifang;Zhang, Xiao;Zheng, Yinan;Wang, Sheng;Dou, Chang;Guo, Liqiong;Byun, Hyang-Min;Motta, Valeria;McCracken, John;Diaz, Anaite;Kang, Choong-Min;Koutrakis, Petros;Bertazzi, Pier Alberto;Li, Jingyun;Schwartz, Joel;Baccarelli, Andrea A.
在流行病学调查中，暴露于颗粒物(PM)与肺癌风险有关。PM的元素成分被认为在PM毒性中具有关键作用，但其与癌症风险相关的分子机制仍然知之甚少。DNA甲基化已成为包括肺癌在内的环境相关疾病的一种很有前途的生物标志物。在这项研究中，我们评估了PM元素成分对北京中国高暴露人群中三个串联重复序列甲基化的影响。北京卡车司机空气污染研究是在2008年北京奥运会前不久(2008年6月15日至7月27日)进行的，调查对象包括60名卡车司机和60名上班族。在间隔1-2周的两天，我们测量了SATPM2.5DNA甲基化、NbL2、D4Z4和暴露于α中八种元素铝(Al)、硅(Si)、硫(S)、钾(K)、钙(Ca)、钛(Ti)、铁(Fe)和锌(Zn)。在对PM2.5质量和其他协变量进行调整的广义估计方程(GEE)模型中，我们估计了单个元素组分与每个串联重复序列甲基化的相关性。在被检测的8种元素中，NbL2甲基化与卡车司机体内的硅(0.121，95%CI：0.030；0.212，FDR=0.047)和钙(0.065，95%CI：0.014；0.115，FDR=0.047)呈正相关。在上班族中，α甲基化与S浓度呈正相关(0.115，95%CI：0.034；0.196，FDR=0.042)。PM相关的血液串联重复甲基化的差异可能有助于检测暴露的生物效应，并识别最终可能经历更高肺癌风险的个人。
Exposure to particulate matter (PM) has been associated with lung cancer risk in epidemiology investigations. Elemental components of PM have been suggested to have critical roles in PM toxicity, but the molecular mechanisms underlying their association with cancer risks remain poorly understood. DNA methylation has emerged as a promising biomarker for environmental-related diseases, including lung cancer. In this study, we evaluated the effects of PM elemental components on methylation of three tandem repeats in a highly-exposed population in Beijing, China. The Beijing Truck Driver Air Pollution Study was conducted shortly before the 2008 Beijing Olympic Games (June 15-July 27, 2008) and included 60 truck drivers and 60 office workers. On two days separated by 1-2 weeks, we measured blood DNA methylation of SATα, NBL2, D4Z4, and personal exposure to eight elemental components in PM2.5, including aluminum (Al), silicon (Si), sulfur (S), potassium (K), calcium (Ca) titanium (Ti), iron (Fe), and zinc (Zn). We estimated the associations of individual elemental component with each tandem repeat methylation in generalized estimating equations (GEE) models adjusted for PM2.5 mass and other covariates. Out of the eight examined elements, NBL2 methylation was positively associated with concentrations of Si (0.121, 95%CI: 0.030; 0.212, FDR=0.047) and Ca (0.065, 95%CI: 0.014; 0.115, FDR=0.047) in truck drivers. In office workers, SATα methylation was positively associated with concentrations of S (0.115, 95%CI: 0.034; 0.196, FDR=0.042). PM-associated differences in blood tandem-repeat methylation may help detect biological effects of the exposure and identify individuals who may eventually experience higher lung cancer risk.
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影响因子：
3.7
作者：
Boks MP;Derks EM;Weisenberger DJ;Strengman E;Janson E;Sommer IE;Kahn RS;Ophoff RA
通讯作者：
Ophoff RA
影响因子：
3.6
作者：
Baccarelli A;Bollati V
通讯作者：
Bollati V
影响因子：
11.4
作者：
Cadle, SH;Mulawa, PA;Snow, R
通讯作者：
Snow, R
影响因子：
11.2
作者：
Bollati, Valentina;Baccarelli, Andrea;Yang, Allen S.
通讯作者：
Yang, Allen S.
影响因子：
4.3
作者：
Deb, Utsab;Lomash, Vinay;Vijayaraghavan, R.
通讯作者：
Vijayaraghavan, R.