Self-folding polymeric containers for encapsulation and delivery of drugs.
Self-folding polymeric containers for encapsulation and delivery of drugs.
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DOI：
10.1016/j.addr.2012.02.012
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发表时间：
2012-11
影响因子：
16.1
通讯作者：
Gracias, David H.
中科院分区：
文献类型：
--
作者：
Fernandes, Rohan;Gracias, David H.
自折叠广义上是指自组装过程，其中薄膜或互连的平面模板弯曲、卷起或折叠成三维（3D）结构，例如圆柱形管、螺旋、波纹片或多面体。该过程已被证明与金属，半导体和聚合物薄膜，并已被用于弯曲管直径小至2纳米和折叠多面体小至100纳米，表面图案化分辨率为15纳米。自折叠方法对于药物递送应用是重要的，因为它们提供了实现具有良好定制的组成、尺寸、形状、壁厚、孔隙率、表面图案和化学性质的3D、生物相容性、全聚合物容器的手段。自折叠也是一个高度平行的过程，并且可以在组装过程中封装或自装载治疗货物。各种治疗货物，如小分子，肽，蛋白质，细菌，真菌和哺乳动物细胞已被封装在自折叠聚合物容器。在这篇综述中，我们专注于全聚合物容器的自折叠。我们讨论了由差应力或表面张力驱动的聚合物容器的自折叠的机械方面，自折叠聚合物在药物递送中的应用，我们概述了未来的挑战。
Self-folding broadly refers to self-assembly processes wherein thin films or interconnected planar templates curve, roll-up or fold into three dimensional (3D) structures such as cylindrical tubes, spirals, corrugated sheets or polyhedra. The process has been demonstrated with metallic, semiconducting and polymeric films and has been used to curve tubes with diameters as small as 2 nm and fold polyhedra as small as 100 nm, with a surface patterning resolution of 15 nm. Self-folding methods are important for drug delivery applications since they provide a means to realize 3D, biocompatible, all-polymeric containers with well-tailored composition, size, shape, wall thickness, porosity, surface patterns and chemistry. Self-folding is also a highly parallel process, and it is possible to encapsulate or self-load therapeutic cargo during assembly. A variety of therapeutic cargos such as small molecules, peptides, proteins, bacteria, fungi and mammalian cells have been encapsulated in self-folded polymeric containers. In this review, we focus on self-folding of all-polymeric containers. We discuss the mechanistic aspects of self-folding of polymeric containers driven by differential stresses or surface tension forces, the applications of self-folding polymers in drug delivery and we outline future challenges.
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影响因子：
3.7
作者：
Azam A;Leong TG;Zarafshar AM;Gracias DH
通讯作者：
Gracias DH
影响因子：
6.1
作者：
Ainslie KM;Desai TA
通讯作者：
Desai TA
DOI：
10.1021/la1013889
发表时间：
2010-11-02
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Cho JH;Azam A;Gracias DH
通讯作者：
Gracias DH
影响因子：
3.6
作者：
de Langre, E.;Baroud, C. N.;Reverdy, P.
通讯作者：
Reverdy, P.
影响因子：
56.9
作者：
Cukierman, E;Pankov, R;Yamada, KM
通讯作者：
Yamada, KM