Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing.
Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing.
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DOI：
10.1039/b806446f
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发表时间：
2008-11
期刊：
影响因子：
6.1
通讯作者：
Desai TA
中科院分区：
文献类型：
--
作者：
Ainslie KM;Desai TA
通过采用最初在微电子行业开发的微制造技术，用于药物递送、组织工程和生物传感的新型设备已被设计用于体内使用。植入体微制造使用包括光刻和微加工在内的广泛技术来制造具有从0.1微米到数百微米的特征的高纵横比和精确特征的设备。微制造提供了与它们所应用的组织和细胞相关的器件特征规模，以及提供了易于整体制造、小器件尺寸和集成电路技术的轻松整合。利用这些方法，药物传递应用已经被开发为通过包括静脉注射、口服和透皮在内的许多传递途径在体内使用。此外，新的微制造组织工程方法提出了心血管、整形外科和眼睛系统等的治疗方案。生物传感装置已经被设计成通过酶-电化学反应和通过机械加载的传感器位移来检测体内的各种分析物和条件。总体而言，微型制造设备的影响已经对广泛的疗法和组织产生了影响。这篇综述介绍了许多这样的器件，重点介绍了它们的制造，并讨论了与微制造技术相关的材料。
By adapting microfabrication techniques originally developed in the microelectronics industry novel device for drug delivery, tissue engineering and biosensing have been engineered for in vivo use. Implant microfabrication uses a broad range of techniques including photolithography, and micromachining to create devices with features ranging from 0.1 to hundreds of microns with high aspect ratios and precise features. Microfabrication offers device feature scale that is relevant to the tissues and cells to which they are applied, as well as offering ease of en masse fabrication, small device size, and facile incorporation of integrated circuit technology. Utilizing these methods, drug delivery applications have been developed for in vivo use through many delivery routes including intravenous, oral, and transdermal. Additionally, novel microfabricated tissue engineering approaches propose therapies for the cardiovascular, orthopedic, and ocular systems, among others. Biosensing devices have been designed to detect a variety of analytes and conditions in vivo through both enzymatic-electrochemical reaction and sensor displacement through mechanical loading. Overall, the impact of microfabricated devices has had an impact over a broad range of therapies and tissues. This review addresses many of these devices and highlights their fabrication as well as discusses materials relevant to microfabrication techniques.
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影响因子：
10.8
作者：
Ahmed, A;Bonner, C;Desai, TA
通讯作者：
Desai, TA
影响因子：
10.8
作者：
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影响因子：
10.8
作者：
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影响因子：
6.1
作者：
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通讯作者：
Desai, Tejal A.
影响因子：
6.7
作者：
Chen, SQ;Zhu, ZQ;Li, S
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