Bioengineering Approaches for Bladder Regeneration.
Bioengineering Approaches for Bladder Regeneration.
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DOI：
10.3390/ijms19061796
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发表时间：
2018-06-17
影响因子：
5.6
通讯作者：
Moreno-Manzano V
中科院分区：
文献类型：
--
作者：
Serrano-Aroca Á;Vera-Donoso CD;Moreno-Manzano V
目前的临床策略膀胱重建或替代相关的严重问题。因此，新的替代方法变得越来越必要。本文的目的是回顾当前生物工程技术在膀胱再生方面的进展和障碍。组织膀胱工程需要一种理想的工程膀胱支架，由一种生物相容性材料组成，适合于维持膀胱填充和排空所需的机械力。此外，一个工程膀胱需要重建柔顺的肌肉壁和高度特化的尿路上皮，在自主神经和感觉神经的控制下精心安排。生物反应器在生理环境中发挥着非常重要的作用，允许细胞生长和特化成组织工程血管结构。生物打印技术正在迅速发展，使用越来越多的不同聚合物作为墨水，实现了定制结构支撑的产生，具有很高的再现能力。虽然取得了许多有希望的结果，但很少有临床试验取得成功。缺乏令人满意的应用是使该领域的研究人员气馁的一个很好的理由，并解释了在过去十年中该领域有限的高影响力科学成果，强调在生物工程膀胱在临床环境中成为普遍存在之前仍需要取得更多进展。
Current clinical strategies for bladder reconstruction or substitution are associated to serious problems. Therefore, new alternative approaches are becoming more and more necessary. The purpose of this work is to review the state of the art of the current bioengineering advances and obstacles reported in bladder regeneration. Tissue bladder engineering requires an ideal engineered bladder scaffold composed of a biocompatible material suitable to sustain the mechanical forces necessary for bladder filling and emptying. In addition, an engineered bladder needs to reconstruct a compliant muscular wall and a highly specialized urothelium, well-orchestrated under control of autonomic and sensory innervations. Bioreactors play a very important role allowing cell growth and specialization into a tissue-engineered vascular construct within a physiological environment. Bioprinting technology is rapidly progressing, achieving the generation of custom-made structural supports using an increasing number of different polymers as ink with a high capacity of reproducibility. Although many promising results have been achieved, few of them have been tested with clinical success. This lack of satisfactory applications is a good reason to discourage researchers in this field and explains, somehow, the limited high-impact scientific production in this area during the last decade, emphasizing that still much more progress is required before bioengineered bladders become a commonplace in the clinical setting.
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影响因子：
14
作者：
Brown, AL;Farhat, W;Woodhouse, KA
通讯作者：
Woodhouse, KA
影响因子：
6.6
作者：
ATALA, A;BAUER, SB;RETIK, AB
通讯作者：
RETIK, AB
影响因子：
4
作者：
Arenas-Herrera, J. E.;Ko, I. K.;Yoo, J. J.
通讯作者：
Yoo, J. J.
影响因子：
--
作者：
Ahvaz, Hana Hanaee;Mobasheri, Hamid;Soleimani, Masoud
通讯作者：
Soleimani, Masoud
影响因子：
4.7
作者：
Chan YY;Sandlin SK;Kurzrock EA;Osborn SL
通讯作者：
Osborn SL