Brain-predicted age difference is associated with cognitive processing in later-life.
Brain-predicted age difference is associated with cognitive processing in later-life.
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DOI：
10.1016/j.neurobiolaging.2021.10.007
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发表时间：
2022-01
影响因子：
4.2
通讯作者：
ASPREE investigator group
中科院分区：
文献类型：
--
作者：
Wrigglesworth J;Yaacob N;Ward P;Woods RL;McNeil J;Storey E;Egan G;Murray A;Shah RC;Jamadar SD;Trevaks R;Ward S;Harding IH;Ryan J;ASPREE investigator group
脑年龄是一种基于神经影像学的衰老生物标志物。这项研究探讨了大脑年龄和实际年龄（brain-PAD）之间的差异是否与基线和纵向认知功能相关。参与者相对健康，主要是社区居住的白人老年人（n = 531，年龄≥70岁），具有较高的教育程度（61%≥12岁）和社会经济地位（59%≥75%）。使用算法根据 T1 加权磁共振图像估算大脑年龄。在控制了年龄、性别、教育程度、抑郁症和体重指数后，brain-PAD 与基线时的精神运动速度（符号数字模态测试）呈负相关（Bonferroni p < 0.006），但与基线语言流畅性（受控口语关联测试）、延迟回忆（霍普金斯学习测试修订版）或一般认知状态（简易精神状态检查）无关。基线 Brain-PAD 与 3 年认知变化无关 (Bonferroni p > 0.006)。这些发现表明，即使在相对健康的老年人中，大脑老化加速也与精神运动速度较差相关，但未来需要对大脑 PAD 的变化进行纵向研究。
Brain age is a neuroimaging-based biomarker of aging. This study examined whether the difference between brain age and chronological age (brain-PAD) is associated with cognitive function at baseline and longitudinally. Participants were relatively healthy, predominantly white community-dwelling older adults (n = 531, aged ≥70 years), with high educational attainment (61% ≥12 years) and socioeconomic status (59% ≥75th percentile). Brain age was estimated from T1-weighted magnetic resonance images using an algorithm by. After controlling for age, gender, education, depression and body mass index, brain-PAD was negatively associated with psychomotor speed (Symbol Digit Modalities Test) at baseline (Bonferroni p < 0.006), but was not associated with baseline verbal fluency (Controlled Oral Word Association Test), delayed recall (Hopkins Learning Test Revised), or general cognitive status (Mini-Mental State Examination). Baseline brain-PAD was not associated with 3-year change in cognition (Bonferroni p > 0.006). These findings indicate that even in relatively healthy older people, accelerated brain aging is associated with worse psychomotor speed, but future longitudinal research into changes in brain-PAD is needed.
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影响因子：
11.2
作者：
Cole, James H.;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
3.7
作者：
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通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
5.7
作者：
Franke, Katja;Ziegler, Gabriel;Gaser, Christian
通讯作者：
Gaser, Christian
影响因子：
2.2
作者：
ASPREE Investigator Group
通讯作者：
ASPREE Investigator Group