Oral health and coronary heart disease.
Oral health and coronary heart disease.
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DOI：
10.1186/s12903-016-0316-7
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发表时间：
2016-11-15
期刊：
影响因子：
2.9
通讯作者：
Mathews GE
中科院分区：
文献类型：
--
作者：
Mathews MJ;Mathews EH;Mathews GE
有充分证据表明，牙周病等口腔健康状况不佳与冠心病 (CHD) 之间存在一定的相关性。目前尚不清楚这种相关性是由于因果关系还是由炎症等共同的潜在疾病引起的。与牙周病相关的冠心病发病途径的合适综合模型可能有助于阐明这种关联。目前文献中还没有这样的模型。先前开发的 CHD 综合模型用于研究牙周病与 CHD 生物标志物之间的潜在发病途径。创建集成模型的目的是为了深入了解 CHD 和牙周病背后可能存在的高阶生物相互作用。为了简化这些交互，开发了一种新颖的“连接图”。它定量地说明了牙周病与冠心病各种血清学生物标志物之间的关系。牙周炎的发病机制显示出多种可能的途径将牙周炎与冠心病发病机制联系起来。开发了一种 CHD 综合模型，总结了牙周病对 CHD 的潜在影响。进一步的研究必须完善和验证模型。
It is well documented that there is some correlation between poor oral health in the form of periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a causal relationship or shared underlying disorder such as inflammation. A suitable integrated model of the CHD pathogenetic pathways relevant to periodontal disease may help to elucidate the association. Such a model is currently not available in literature. A previously developed integrated model of CHD was used to investigate potential pathogenetic pathways linking periodontal disease to CHD biomarkers. The integrated model was created to provide insight into possible higher-order biological interactions underlying CHD and periodontal disease. In order to simplify these interactions a novel ‘connection graph’ was developed. It quantitatively illustrates the relationship between periodontal disease and various serological biomarkers of CHD. The pathogenesis of periodontitis shows various possible pathways which could link periodontitis to CHD pathogenesis. An integrated model of CHD was developed which provides a summary of the potential CHD effects of periodontal disease. Further research must refine and validate the model.
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影响因子：
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