Proinflammatory and oxidative stress markers in patients with periodontal disease.
Proinflammatory and oxidative stress markers in patients with periodontal disease.
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DOI：
10.1155/2007/45794
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发表时间：
2007
影响因子：
4.6
通讯作者：
Fröde TS
中科院分区：
文献类型：
--
作者：
Borges I Jr;Moreira EA;Filho DW;de Oliveira TB;da Silva MB;Fröde TS
目标。评估慢性牙周炎患者牙龈组织中促炎和氧化应激标志物的参与情况。主题和方法。18名受试者分为实验组（年龄）和对照组（年龄）两组。研究了近端牙龈组织中过氧化氢酶、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽s转移酶（GST）、谷胱甘肽还原酶等酶促抗氧化剂的活性，以及总谷胱甘肽和还原性谷胱甘肽、氧化谷胱甘肽（GSSG）、硫代巴比妥酸活性物质（TBARS）和髓过氧化物酶（MPO）的活性。组间的统计差异由独立的学生测试和。结果。与对照组相比，牙周病患者牙龈组织中MPO、GPx、GST活性以及TBARS和GSSG水平显著升高（）。结论。本研究结果显示氧化应激生物标志物与牙周病之间存在重要的相关性。
Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Subject and methods. Eighteen subjects were divided in two groups: experimental (age ) and control (age ). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student test and . Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (). Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
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影响因子：
6.7
作者：
Brock, GR;Butterworth, CJ;Chapple, ILC
通讯作者：
Chapple, ILC
影响因子：
3.3
作者：
Battino, M;Ferreiro, MS;Bullon, P
通讯作者：
Bullon, P
DOI：
10.1073/pnas.0504398102
发表时间：
2005-09-27
影响因子：
11.1
作者：
Fratelli, M;Goodwin, LO;Ghezzi, P
通讯作者：
Ghezzi, P
影响因子：
6.8
作者：
Oakley, AJ
通讯作者：
Oakley, AJ
影响因子：
6.7
作者：
CHEESEMAN, KH;SLATER, TF
通讯作者：
SLATER, TF