Opioid use as a proximal risk factor for suicidal behavior in young adults.
Opioid use as a proximal risk factor for suicidal behavior in young adults.
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DOI：
10.1111/sltb.12806
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发表时间：
2022-04
影响因子：
3.2
通讯作者：
Melhem, Nadine M.
中科院分区：
文献类型：
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作者：
Marengo, Laura;Douaihy, Antoine;Zhong, Yongqi;Krancevich, Katie;Brummit, Bradley;Sakolsky, Dara;Deal, Meredith;Zelazny, Jamie;Goodfriend, Eli;Saul, Melissa;Murata, Stephen;Thoma, Brian;Mansour, Hader;Tew, Jamie;Ahmed, Nadeem;Marsland, Anna;Brent, David;Melhem, Nadine M.
与过量死亡有关的阿片类药物的流行伴随着自杀率的上升，特别是在青少年和年轻人中。然而，关于阿片类药物的使用是否可以预测年轻人的自杀行为的研究有限。我们的样本包括183名精神病患者(18-30岁)，他们因自杀未遂(SA)而入院，有自杀意念(SI)，并有无自杀意念或企图的精神对照(PC)。自杀行为使用哥伦比亚自杀严重程度评定量表进行评估。另设健康对照组(HC；n=40)。对患者和对照组进行了一年多的跟踪调查。采用方差分析、回归分析和Cox回归分析。在基线水平上，SA[β=0.87，CI(0.1-1.6)，p=0.02]和SI[β=0.75，CI(0.03-1.5)，p=0.04]在过去一年中使用阿片类药物的可能性显著高于HC。阿片类药物的使用与焦虑症状[β=0.75，CI(0.001-1.5)，p=0.05]、创伤后应激障碍症状[β=3.9，CI(1.1-6.7)，p=0.01]和攻击性[β=0.02，CI(0.01-0.04)，p=0.02]相关。入院前一个月使用阿片类药物预测6个月后SA[OR=1.87，CI(1.06~3.31)，P=0.032]。阿片类药物的使用是SA的近端预测因素。这些发现可能有助于临床医生更好地识别有自杀行为风险的患者，从而允许更个性化的治疗方法。
There is a concomitant rise in suicide rates with the prevalence of opioids involved in overdose deaths, especially among adolescents and young adults. However, there are limited studies on whether opioid use prospectively predict suicidal behavior in youth. Our sample included 183 psychiatric patients (18–30 years) admitted for a suicide attempt (SA), have current suicidal ideation (SI), and psychiatric controls without ideation or attempt (PC). Suicidal behavior was assessed using the Columbia-Suicide Severity Rating Scale. We also recruited a healthy control group (HC; n=40). Patients and controls were followed over a year. ANOVA, regression, and cox regression were used. SA [β=0.87, CI (0.1–1.6), p=0.02] and SI [β=0.75, CI (0.03–1.5), p=0.04] were significantly more likely than HCs to have used opioids in the past year at baseline. Opioid use was associated with increased anxiety symptoms [β=0.75, CI (0.001–1.5), p=0.05], PTSD symptoms [β=3.90, CI (1.1–6.7), p=0.01], and aggression [β=0.02, CI (0.01–0.04), p=0.02]. Opioid use in the month prior to hospitalization predicted SA at 6 months [OR=1.87, CI (1.06–3.31), p=0.032]. Opioid use is a proximal predictor for SA. These findings may help clinicians better identify patients at risk for suicidal behavior, allowing for more personalized treatment approaches.
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DOI：
10.1111/jcpp.12831
发表时间：
2018-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Cha CB;Franz PJ;M Guzmán E;Glenn CR;Kleiman EM;Nock MK
通讯作者：
Nock MK
影响因子：
3.7
作者：
Darvishi N;Farhadi M;Haghtalab T;Poorolajal J
通讯作者：
Poorolajal J
影响因子：
6.9
作者：
Boden, J. M.;Fergusson, D. M.;Horwood, L. J.
通讯作者：
Horwood, L. J.
影响因子：
6
作者：
Bohnert, Kipling M.;Ilgen, Mark A.;Katz, Ira R.
通讯作者：
Katz, Ira R.
影响因子：
13.8
作者：
Gaither, Julie R.;Shabanova, Veronika;Leventhal, John M.
通讯作者：
Leventhal, John M.