Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis.
Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis.
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DOI：
10.1371/journal.pone.0126870
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Poorolajal J
中科院分区：
文献类型：
--
作者：
Darvishi N;Farhadi M;Haghtalab T;Poorolajal J
几项原创研究调查了酒精使用障碍（AUD）对自杀想法和行为的影响，但各个研究之间存在严重差异。因此，需要对 AUD 与自杀之间的关联进行系统评估。我们检索了 PubMed、Web of Science 和 Scopus，直至 2015 年 2 月。我们还检索了 Psycinfo 网站和期刊并联系了作者。我们纳入了针对 AUD 与自杀之间关联的观察性（队列、病例对照和横断面）研究。利息敞口为澳元。主要结局是自杀意念、自杀企图和自杀完成。我们使用 Q 检验和 I2 统计来评估异质性。我们使用 Egger 和 Begg 测试以及漏斗图探讨了发表偏倚。我们使用随机效应模型对数据进行了元分析。对于每个结果，我们计算了总体比值比 (OR) 或风险比 (RR)，置信区间 (CI) 为 95%。我们纳入了 8548 项检索研究中的 31 项，共有 420,732 名参与者。 AUD 与自杀意念 (OR=1.86; 95% CI: 1.38, 2.35)、自杀企图 (OR=3.13; 95% CI: 2.45, 3.81) 之间存在显着相关性。并完成自杀（OR=2.59；95% CI：1.95、3.23；RR=1.74；95% CI：1.26、2.21）。这些研究之间存在显着的异质性，但很少担心存在发表偏倚。有足够的证据表明AUD显着增加自杀意念、自杀未遂和自杀完成的风险。因此，AUD可以被认为是自杀的重要预测因素和过早死亡的重要根源。
Several original studies have investigated the effect of alcohol use disorder (AUD) on suicidal thought and behavior, but there are serious discrepancies across the studies. Thus, a systematic assessment of the association between AUD and suicide is required. We searched PubMed, Web of Science, and Scopus until February 2015. We also searched the Psycinfo web site and journals and contacted authors. We included observational (cohort, case-control, and cross-sectional) studies addressing the association between AUD and suicide. The exposure of interest was AUD. The primary outcomes were suicidal ideation, suicide attempt, and completed suicide. We assessed heterogeneity using Q-test and I2 statistic. We explored publication bias using the Egger's and Begg's tests and funnel plot. We meta-analyzed the data with the random-effects models. For each outcome we calculated the overall odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CI). We included 31 out of 8548 retrieved studies, with 420,732 participants. There was a significant association between AUD and suicidal ideation (OR=1.86; 95% CI: 1.38, 2.35), suicide attempt (OR=3.13; 95% CI: 2.45, 3.81); and completed suicide (OR=2.59; 95% CI: 1.95, 3.23 and RR=1.74; 95% CI: 1.26, 2.21). There was a significant heterogeneity among the studies, but little concern to the presence of publication bias. There is sufficient evidence that AUD significantly increases the risk of suicidal ideation, suicide attempt, and completed suicide. Therefore, AUD can be considered an important predictor of suicide and a great source of premature death.
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影响因子：
6.6
作者：
Bernal, M.;Haro, J. M.;Alonso, J.
通讯作者：
Alonso, J.
影响因子：
5.5
作者：
Coêlho, Bruno Mendonça;Andrade, Laura Helena;Wang, Yuan-Pang
通讯作者：
Wang, Yuan-Pang
影响因子：
2.1
作者：
Bunevicius R;Liaugaudaite V;Peceliuniene J;Raskauskiene N;Bunevicius A;Mickuviene N
通讯作者：
Mickuviene N
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
6.6
作者：
BECK, AT;STEER, RA
通讯作者：
STEER, RA