Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat.
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat.
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DOI：
10.3389/fnbeh.2014.00289
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发表时间：
2014
影响因子：
3
通讯作者：
Dranovsky A
中科院分区：
文献类型：
--
作者：
Kirshenbaum GS;Lieberman SR;Briner TJ;Leonardo ED;Dranovsky A
最近的证据表明，成年海马区的神经发生在调节应激的行为和生理反应中起作用。海马神经发生在整个生命周期，然而，与成年小鼠相比，青春期小鼠的细胞出生率高出300%。青春期是发育的敏感期，情感回路和应激反应经历了可塑性，建立了终生的设定点。因此，发生在青春期的神经发生对情绪行为可能特别重要。然而，人们对青春期出生的海马神经元的功能知之甚少。为了评估青春期出生的神经元对成年应激反应和抑郁相关行为的贡献，我们在青春期或成年期间暂时减少了GFAP-TK小鼠的细胞增殖。我们发现，青春期的干预不会改变成人在强迫游泳测试、蔗糖偏好测试或社会隶属测试中的基线行为反应，也不会改变成人对急性应激源的皮质酮反应。然而，在长期的社会失败之后，青春期神经发生减少的成年小鼠表现出弹性表型。成人神经发生的类似一过性减少不会影响抑郁样行为或应激诱导的皮质酮。我们的研究表明，在青春期出生的海马神经元，而不是在成年期出生的海马神经元，对慢性社交失败具有重要的易感性。
Recent evidence implicates adult hippocampal neurogenesis in regulating behavioral and physiologic responses to stress. Hippocampal neurogenesis occurs across the lifespan, however the rate of cell birth is up to 300% higher in adolescent mice compared to adults. Adolescence is a sensitive period in development where emotional circuitry and stress reactivity undergo plasticity establishing life-long set points. Therefore neurogenesis occurring during adolescence may be particularly important for emotional behavior. However, little is known about the function of hippocampal neurons born during adolescence. In order to assess the contribution of neurons born in adolescence to the adult stress response and depression-related behavior, we transiently reduced cell proliferation either during adolescence, or during adulthood in GFAP-Tk mice. We found that the intervention in adolescence did not change adult baseline behavioral response in the forced swim test, sucrose preference test or social affiliation test, and did not change adult corticosterone responses to an acute stressor. However following chronic social defeat, adult mice with reduced adolescent neurogenesis showed a resilient phenotype. A similar transient reduction in adult neurogenesis did not affect depression-like behaviors or stress induced corticosterone. Our study demonstrates that hippocampal neurons born during adolescence, but not in adulthood are important to confer susceptibility to chronic social defeat.
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影响因子：
56.9
作者：
Santarelli, L;Saxe, M;Hen, R
通讯作者：
Hen, R
影响因子：
16.2
作者：
Richardson-Jones, Jesse W.;Craige, Caryne P.;Guiard, Bruno P.;Stephen, Alisson;Metzger, Kayla L.;Kung, Hank F.;Gardier, Alain M.;Dranovsky, Alex;David, Denis J.;Beck, Sheryl G.;Hen, Rene;Leonardo, E. David
通讯作者：
Leonardo, E. David
影响因子：
25
作者：
Denise, A;Garcia, R;Sofroniew, MV
通讯作者：
Sofroniew, MV
影响因子：
2.2
作者：
Romeo, Russell D.
通讯作者：
Romeo, Russell D.
影响因子：
2.5
作者：
Nadler, JJ;Moy, SS;Crawley, JN
通讯作者：
Crawley, JN