Inhibition and dispersal of Agrobacterium tumefaciens biofilms by a small diffusible Pseudomonas aeruginosa exoproduct(s).
Inhibition and dispersal of Agrobacterium tumefaciens biofilms by a small diffusible Pseudomonas aeruginosa exoproduct(s).
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DOI：
10.1007/s00203-011-0767-9
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发表时间：
2012-06
影响因子：
2.8
通讯作者：
Fuqua, Clay
中科院分区：
文献类型：
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作者：
Hibbing, Michael E.;Fuqua, Clay
环境生物膜通常包含不同物种的混合种群。在这些密集的群落中，生物膜居民之间对有限营养物质（如铁）的竞争可能是激烈的，导致影响竞争者生长或形成生物膜的能力的竞争因素的演变。我们已经发现了存在于铜绿假单胞菌的条件培养液中的化合物，其分散并抑制由兼性植物病原体根癌土壤杆菌产生的生物膜的形成。当铜绿假单胞菌在铁限制条件下培养时，强烈诱导抑制活性，但其不通过铁螯合起作用。此外，抑制活性的产生不受全局铁调节蛋白Fur、铁响应性细胞质外功能（ECF）σ因子PvdS或三种公认的铜绿假单胞菌群体感应系统的调节。此外，负责抑制和分散A.根癌农杆菌生物膜形成可能与最近鉴定的铜绿假单胞菌分散因子顺式-2-癸烯酸（CDA）不同，因为培养液的透析显示抑制化合物大于CDA，并且培养液分散并抑制由A.根癌农杆菌对铜绿假单胞菌生物被膜的形成没有影响。
Environmental biofilms often contain mixed populations of different species. In these dense communities, competition between biofilm residents for limited nutrients such as iron, can be fierce, leading to the evolution of competitive factors that affect the ability of competitors to grow or form biofilms. We have discovered a compound(s) present in the conditioned culture fluids of Pseudomonas aeruginosa that disperses and inhibits the formation of biofilms produced by the facultative plant pathogen Agrobacterium tumefaciens. The inhibitory activity is strongly induced when P. aeruginosa is cultivated in iron-limited conditions, but it does not function through iron sequestration. In addition, the production of the inhibitory activity is not regulated by the global iron regulatory protein Fur, the iron-responsive extra-cytoplasmic function (ECF) σ factor PvdS, or three of the recognized P. aeruginosa quorum sensing systems. In addition, the compound(s) responsible for the inhibition and dispersal of A. tumefaciens biofilm formation is likely distinct from the recently identified P. aeruginosa dispersal factor, cis-2-decenoic acid (CDA), as dialysis of the culture fluids showed that the inhibitory compound was larger than CDA and culture fluids that dispersed and inhibited biofilm formation by A. tumefaciens had no effect on biofilm formation by P. aeruginosa.
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影响因子：
2.1
作者：
Irie, Y;O'Toole, GA;Yuk, MH
通讯作者：
Yuk, MH
影响因子：
3.6
作者：
Boles, BR;Thoendel, M;Singh, PK
通讯作者：
Singh, PK
影响因子：
3.5
作者：
Chipperfield, JR;Ratledge, C
通讯作者：
Ratledge, C
影响因子：
2.6
作者：
Joshi, Falguni;Archana, G.;Desai, Anjana
通讯作者：
Desai, Anjana
DOI：
10.1038/nrmicro2259
发表时间：
2010-01
期刊：
Nature reviews. Microbiology
影响因子：
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作者：
通讯作者：
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