Altered Circadian Timing System-Mediated Non-Dipping Pattern of Blood Pressure and Associated Cardiovascular Disorders in Metabolic and Kidney Diseases.
Altered Circadian Timing System-Mediated Non-Dipping Pattern of Blood Pressure and Associated Cardiovascular Disorders in Metabolic and Kidney Diseases.
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DOI：
10.3390/ijms19020400
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发表时间：
2018-01-30
影响因子：
5.6
通讯作者：
Kobori H
中科院分区：
文献类型：
--
作者：
Rahman A;Hasan AU;Nishiyama A;Kobori H
早晨血压（BP）的激增与心血管（CV）事件的增加相一致。这强烈表明，血压昼夜节律的改变在心血管疾病（CVD）的发展中起着至关重要的作用。血压昼夜节律紊乱，如非下降型高血压（即，没有夜间血压下降），经常在代谢紊乱和慢性肾病（CKD）中观察到。昼夜节律计时系统由下丘脑视交叉上核的中枢时钟和/或心脏、血管系统和肾脏的外周时钟控制，调节BP的24小时振荡。然而，关于代谢紊乱和CKD中昼夜节律计时系统改变介导的BP下降模式中断的分子和细胞机制的信息很少，这可能导致CV事件的发生。对这一发病机制的更深入了解可以为CVD的管理提供新的治疗策略。这篇简短的综述将讨论我们和其他人最近关于可能影响代谢功能障碍和肾脏疾病中BP下降模式及其与CV疾病相关性的分子机制的研究结果。
The morning surge in blood pressure (BP) coincides with increased cardiovascular (CV) events. This strongly suggests that an altered circadian rhythm of BP plays a crucial role in the development of CV disease (CVD). A disrupted circadian rhythm of BP, such as the non-dipping type of hypertension (i.e., absence of nocturnal BP decline), is frequently observed in metabolic disorders and chronic kidney disease (CKD). The circadian timing system, controlled by the central clock in the suprachiasmatic nucleus of the hypothalamus and/or by peripheral clocks in the heart, vasculature, and kidneys, modulates the 24 h oscillation of BP. However, little information is available regarding the molecular and cellular mechanisms of an altered circadian timing system-mediated disrupted dipping pattern of BP in metabolic disorders and CKD that can lead to the development of CV events. A more thorough understanding of this pathogenesis could provide novel therapeutic strategies for the management of CVD. This short review will address our and others’ recent findings on the molecular mechanisms that may affect the dipping pattern of BP in metabolic dysfunction and kidney disease and its association with CV disorders.
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影响因子：
3.7
作者：
Anea CB;Zhang M;Chen F;Ali MI;Hart CM;Stepp DW;Kovalenkov YO;Merloiu AM;Pati P;Fulton D;Rudic RD
通讯作者：
Rudic RD
影响因子：
3.3
作者：
Agez, L.;Laurent, V.;Gauer, F.
通讯作者：
Gauer, F.
影响因子：
1.1
作者：
Chudy, Peter;Kotulicova, Daniela;Kubisz, Peter
通讯作者：
Kubisz, Peter
DOI：
10.1196/annals.1353.008
发表时间：
2006-01-01
期刊：
PHEOCHROMOCYTOMA
影响因子：
--
作者：
Dabrowska, Elzbieta;Lewandowski, Jacek;Gaciong, Zbigniew
通讯作者：
Gaciong, Zbigniew
影响因子：
37.8
作者：
Anea CB;Zhang M;Stepp DW;Simkins GB;Reed G;Fulton DJ;Rudic RD
通讯作者：
Rudic RD