High-Resolution MR Imaging of the Human Brainstem In vivo at 7 Tesla.
High-Resolution MR Imaging of the Human Brainstem In vivo at 7 Tesla.
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DOI：
10.3389/fnhum.2013.00710
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发表时间：
2013
影响因子：
2.9
通讯作者：
Reichenbach JR
中科院分区：
文献类型：
--
作者：
Deistung A;Schäfer A;Schweser F;Biedermann U;Güllmar D;Trampel R;Turner R;Reichenbach JR
脑干是由大量的轴突神经纤维和神经核组成的，在人脑中起着重要的功能作用。因此，以高空间分辨率非侵入性地描绘其解剖结构可以反过来帮助更好地将正常和病理解剖变化与医学状况以及神经和外周功能相关联。我们探索了7T高分辨率磁共振成像（MRI）的潜力，通过采集和生成具有多种对比度的图像来描绘人体脑干的复杂解剖结构：T2加权图像、纵向弛豫率（R1图）和有效横向弛豫率（图）的定量图、磁化率图和方向编码的轨道密度图像。将图像和定量图与组织学染色和解剖图谱进行比较，以识别神经核和神经纤维。在所调查的对比中，磁化率图显示脑干结构的数量最多。与R1图和T2加权图像相反，它们显示了相当均匀的对比度，图，磁化率图和轨道密度图像清楚地显示了大量较小和较大的纤维束。在脑桥和延髓的切片中可识别出几个脑干核团，包括磁化率图上的三叉神经脊束核和网状被盖核以及R1、和磁化率图上的下橄榄核。在所有对比中，黑质和红核均可见。总之，高分辨率，多对比度MR成像在7 T是一个通用的工具，非侵入性评估的个人解剖结构和组织组成的人脑干。
The human brainstem, which comprises a multitude of axonal nerve fibers and nuclei, plays an important functional role in the human brain. Depicting its anatomy non-invasively with high spatial resolution may thus in turn help to better relate normal and pathological anatomical variations to medical conditions as well as neurological and peripheral functions. We explored the potential of high-resolution magnetic resonance imaging (MRI) at 7 T for depicting the intricate anatomy of the human brainstem in vivo by acquiring and generating images with multiple contrasts: T2-weighted images, quantitative maps of longitudinal relaxation rate (R1 maps) and effective transverse relaxation rate ( maps), magnetic susceptibility maps, and direction-encoded track-density images. Images and quantitative maps were compared with histological stains and anatomical atlases to identify nerve nuclei and nerve fibers. Among the investigated contrasts, susceptibility maps displayed the largest number of brainstem structures. Contrary to R1 maps and T2-weighted images, which showed rather homogeneous contrast, maps, magnetic susceptibility maps, and track-density images clearly displayed a multitude of smaller and larger fiber bundles. Several brainstem nuclei were identifiable in sections covering the pons and medulla oblongata, including the spinal trigeminal nucleus and the reticulotegmental nucleus on magnetic susceptibility maps as well as the inferior olive on R1, , and susceptibility maps. The substantia nigra and red nuclei were visible in all contrasts. In conclusion, high-resolution, multi-contrast MR imaging at 7 T is a versatile tool to non-invasively assess the individual anatomy and tissue composition of the human brainstem.
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影响因子：
4.4
作者：
Haacke, E. M.;Tang, J.;Neelavalli, J.;Cheng, Y. C. N.
通讯作者：
Cheng, Y. C. N.
影响因子：
5.7
作者：
de Leeuw, H.;Bakker, C. J. G.
通讯作者：
Bakker, C. J. G.
影响因子：
5.7
作者：
Calamante, Fernando;Tournier, Jacques-Donald;Connelly, Alan
通讯作者：
Connelly, Alan
影响因子：
3.3
作者：
Deistung, Andreas;Rauscher, Alexander;Reichenbach, Juergen R.
通讯作者：
Reichenbach, Juergen R.
影响因子：
3.3
作者：
Griswold, MA;Jakob, PM;Haase, A
通讯作者：
Haase, A