Behavioral Effects of Chronic Gray and White Matter Stroke Lesions in a Functionally Defined Connectome for Naming.
Behavioral Effects of Chronic Gray and White Matter Stroke Lesions in a Functionally Defined Connectome for Naming.
复制标题
DOI：
10.1177/1545968318780351
复制
发表时间：
2018-06
影响因子：
4.2
通讯作者：
Turkeltaub PE
中科院分区：
文献类型：
--
作者：
Xing S;Mandal A;Lacey EH;Skipper-Kallal LM;Zeng J;Turkeltaub PE
在功能磁共振成像研究中，图片命名涉及广泛分布在顶叶、额叶和颞叶皮层的大脑区域。然而，目前还不清楚这些被激活的区域，沿着与它们之间的白色物质通路，是否真的对命名至关重要。我们的目的是确定与健康老年人命名有关的节点和通路，并测试连接体损伤对命名能力的影响。我们首先确定了24个皮质节点激活的命名任务，并重建这些节点之间的解剖连接，在健康成人的概率纤维束成像。然后，我们使用结构扫描和分数各向异性地图在45例左半球中风，以评估节点和通路的完整性命名，语音和非语言语义能力的关系。我们发现，在控制病变大小和人口统计学因素后，13个左半球白色白质束的背侧和腹侧流和一个半球间束的平均分数各向异性值与命名分数显著相关。相比之下，在控制相同的变量后，皮质节点的病变负荷与命名性能无关。在所识别的纤维束中，左半球腹侧的四条纤维束的完整性与非言语语义加工有关，左半球背侧的一条纤维束与语音加工有关。我们的发现揭示了白色物质结构对命名及其子过程至关重要。这些发现证明了多模式方法的价值，这些方法整合了功能成像，结构连接和病变数据，以了解大脑网络和行为之间的关系。
In fMRI studies, picture naming engages widely distributed brain regions in parietal, frontal and temporal cortices. However, it remains unknown whether those activated areas, along with white matter pathways between them, are actually crucial for naming. We aimed to identify nodes and pathways implicated in naming in healthy older adults, and test the impact of lesions to the connectome on naming ability. We first identified 24 cortical nodes activated by a naming task and reconstructed anatomical connections between these nodes using probabilistic tractography in healthy adults. We then used structural scans and fractional anisotropy maps in 45 patients with left hemisphere stroke to assess the relationships of node and pathway integrity to naming, phonology and nonverbal semantic ability. We found that mean fractional anisotropy values in 13 left hemisphere white matter tracts within the dorsal and ventral streams and one interhemispheric tract significantly related to naming scores after controlling for lesion size and demographic factors. In contrast, lesion loads in the cortical nodes were not related to naming performance after controlling for the same variables. Among the identified tracts the integrity of four left hemisphere ventral stream tracts related to non-verbal semantic processing, and one left hemisphere dorsal stream tract related to phonological processing. Our findings reveal white matter structures vital for naming and its subprocesses. These findings demonstrate the value of multimodal methods that integrate functional imaging, structural connectivity, and lesion data to understand relationships between brain networks and behavior.
登录
查看更多内容
DOI：
10.1093/brain/aws354
发表时间：
2013-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Kümmerer D;Hartwigsen G;Kellmeyer P;Glauche V;Mader I;Klöppel S;Suchan J;Karnath HO;Weiller C;Saur D
通讯作者：
Saur D
DOI：
10.1016/j.cortex.2012.03.001
发表时间：
2013-03
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Baldo JV;Arévalo A;Patterson JP;Dronkers NF
通讯作者：
Dronkers NF
影响因子：
8.3
作者：
Bonilha L;Rorden C;Fridriksson J
通讯作者：
Fridriksson J
影响因子：
3.7
作者：
Fridriksson, Julius;Bonilha, Leonardo;Rorden, Chris
通讯作者：
Rorden, Chris
影响因子：
5.3
作者：
Mandelli, Maria Luisa;Caverzasi, Eduardo;Gorno-Tempini, Maria Luisa
通讯作者：
Gorno-Tempini, Maria Luisa