Grey and white matter correlates of picture naming: evidence from a voxel-based lesion analysis of the Boston Naming Test.
Grey and white matter correlates of picture naming: evidence from a voxel-based lesion analysis of the Boston Naming Test.
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DOI：
10.1016/j.cortex.2012.03.001
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Dronkers NF
中科院分区：
文献类型：
--
作者：
Baldo JV;Arévalo A;Patterson JP;Dronkers NF
最近的一些研究，利用功能性神经影像学和病变分析技术在神经病患者产生了相互矛盾的结果与图片命名的神经相关性。图片命名涉及一系列的认知过程，从视觉感知/识别到词汇语义提取再到发音。这个中间过程，即检索与物体相关的名称的能力，在某些情况下归因于左外侧颞叶的后部，在其他情况下归因于前颞叶皮层。在目前的研究中，我们使用基于体素的病变症状映射（VLSM），以确定在一个大样本的良好表征的左半球（LH）患者患有一系列命名缺陷的图片命名的神经相关。我们对患者进行了波士顿命名测试（BNT），这是一种临床标准化的图片命名测量方法，广泛用于临床和研究环境。我们发现，BNT的整体表现与LH区域网络相关，包括左前至后颞中回（MTG）和上级颞回（STG）的重要部分以及潜在的白色物质，并延伸到左下顶叶皮质。然而，当我们将控制视觉识别和运动言语缺陷的协变量添加到该分析中以分离特定于词汇语义检索的大脑区域时，剩下的重要区域几乎仅限于左中后部MTG和底层白色物质。这些研究结果支持的概念，一个大的网络在左侧大脑外侧叶皮层支持图片命名，但左中后部MTG和底层的白色物质发挥关键作用的核心能力，检索一个名称与一个对象或图片。
A number of recent studies utilizing both functional neuroimaging and lesion analysis techniques in neurologic patients have produced conflicting results with respect to the neural correlates of picture naming. Picture naming involves a number of cognitive processes, from visual perception/recognition to lexical-semantic retrieval to articulation. This middle process, the ability to retrieve a name associated with an object, has been attributed in some cases to posterior portions of the left lateral temporal lobe and in other cases, to anterior temporal cortex. In the current study, we used voxel-based lesion symptom mapping (VLSM) to identify neural correlates of picture naming in a large sample of well-characterized left hemisphere (LH) patients suffering from a range of naming deficits. We tested patients on the Boston Naming Test (BNT), a clinical, standardized measure of picture naming that is widely used in both clinical and research settings. We found that overall performance on the BNT was associated with a network of LH regions that included significant portions of the left anterior to posterior middle temporal gyrus (MTG) and superior temporal gyrus (STG) and underlying white matter, and extended into left inferior parietal cortex. However, when we added covariates to this analysis that controlled for deficits in visual recognition and motor speech in order to isolate brain regions specific to lexical-semantic retrieval, the significant regions that remained were confined almost exclusively to the left mid-posterior MTG and underlying white matter. These findings support the notion that a large network in left peri-Sylvian cortex supports picture naming, but that the left mid-posterior MTG and underlying white matter play a critical role in the core ability to retrieve a name associated with an object or picture.
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