A genotypic trade-off between constitutive resistance to viral infection and host growth rate.
A genotypic trade-off between constitutive resistance to viral infection and host growth rate.
复制标题
对病毒感染和宿主生长速率的构型抵抗之间的基因型权衡。
DOI：
10.1111/evo.13623
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Boots M
中科院分区：
文献类型：
--
作者：
Bartlett LJ;Wilfert L;Boots M
基因型权衡是理解生活史特征进化的基础。特别是，最佳宿主防御的进化和针对传染病的防御变异的维持被认为是由这种进化权衡所支撑的。然而，满足理论模型严格假设的这些权衡的实证论证很少。此外，这些权衡还没有被证明可以使用各种不同的实验方法来排除特定实验设计的混淆问题。在这里，我们使用近交系作为一种新的实验方法来测试先前通过多重选择实验证明的Plodia interpunctella病毒抗性和生长率之间的权衡是否稳健，并满足支持该领域理论工作所需的严格标准。至关重要的是，我们证明这种权衡既是遗传性的，也是本构性的。这一发现有助于支持依赖于这些假设的大量理论，并使这种耐药性的权衡通过多种实验方法得以复制，并明确证明是遗传性和组成性的。
Genotypic trade‐offs are fundamental to the understanding of the evolution of life‐history traits. In particular, the evolution of optimal host defense and the maintenance of variation in defense against infectious disease is thought to be underpinned by such evolutionary trade‐offs. However, empirical demonstrations of these trade‐offs that satisfy the strict assumptions made by theoretical models are rare. Additionally, none of these trade‐offs have yet been shown to be robustly replicable using a variety of different experimental approaches to rule out confounding issues with particular experimental designs. Here, we use inbred isolines as a novel experimental approach to test whether a trade‐off between viral resistance and growth rate in Plodia interpunctella, previously demonstrated by multiple selection experiments, is robust and meets the strict criteria required to underpin theoretical work in this field. Critically, we demonstrate that this trade‐off is both genetic and constitutive. This finding helps support the large body of theory that relies on these assumptions, and makes this trade‐off for resistance unique in being replicated through multiple experimental approaches and definitively shown to be genetic and constitutive.
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影响因子：
2.1
作者：
Ashby, B.;King, K. C.
通讯作者：
King, K. C.
影响因子：
2
作者：
Boots, M;Bowers, RG
通讯作者：
Bowers, RG
影响因子：
2
作者：
Bowers, RG;Hoyle, A;Boots, M
通讯作者：
Boots, M
影响因子：
56.9
作者：
Boots, Michael;Mealor, Michael
通讯作者：
Mealor, Michael
影响因子：
6.3
作者：
Bryant, EH;Reed, DH
通讯作者：
Reed, DH