Bone density in haemophilia: a single institutional cross-sectional study.
Bone density in haemophilia: a single institutional cross-sectional study.
复制标题
DOI：
10.1111/hae.12240
复制
发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Elon L
中科院分区：
文献类型：
--
作者：
Kempton CL;Antun A;Antoniucci DM;Carpenter W;Ribeiro M;Stein S;Slovensky L;Elon L
血友病与低骨密度（BMD）有关。然而，先前对这一人群的临床研究既没有明确地阐明低骨密度发展的危险因素，也没有确定哪些人需要进行骨质疏松筛查。评价骨密度与血友病及其他人口统计学和临床变量的关系。我们对血友病成年男性的骨密度进行了横断面研究。通过放射学研究、体格检查、患者问卷调查和医疗记录的回顾收集预测变量的措施。88名入组受试者中位年龄为41岁（IQR: 20）；股骨颈中位骨密度（n=87） 0.90 g/cm2 (IQR 0.24)；x线关节评分中位数为7.5 （IQR 18）。在年龄<50岁的受试者中（n=62），在控制BMI、酒精、HIV和白种人后，骨密度随关节影像学评分的增加而下降（test .β= - 0.006 mg/cm2; 95%CI = - 0.009, - 0.003；部分R2=0.23）。≥50岁的受试者（n=26）中，38%患有骨质疏松症（T评分≤- 2.5），骨密度与关节病之间无相关性。50岁以下男性血友病患者骨密度低的危险因素包括血友病关节病、低或正常的BMI和HIV。50岁以上的男性血友病患者应该进行骨质疏松症的常规筛查。
Haemophilia has been associated with low bone mineral density (BMD). However, prior clinical studies of this population have neither clearly elucidated risk factors for development of low BMD nor identified who may warrant screening for osteoporosis. To evaluate the relationship between BMD and hemophilic arthropathy and other demographic and clinical variables. We undertook a cross-section study of BMD in adult men with haemophilia. Measures of predictor variables were collected by radiographic studies, physical examination, patient questionnaires, and review of medical records. Among 88 enrolled subjects, the median age was 41 years (IQR: 20); median femoral neck BMD (n=87) was 0.90 g/cm2 (IQR 0.24); and median radiographic joint score was 7.5 (IQR 18). Among subjects <50 years (n=62), after controlling for BMI, alcohol, HIV, and White race, BMD decreased as radiographic joint score increased (est.β=−0.006 mg/cm2; 95%CI −0.009, −0.003; partial R2=0.23). Among subjects ≥ 50 years (n=26), 38% had osteoporosis (T score ≤−2.5) and there was no association between BMD and arthropathy. Risk factors for low BMD in men with haemophilia < 50 years include hemophilic arthropathy, low or normal BMI, and HIV. Men with haemophilia over age 50 years should have routine screening for detection of osteoporosis.
登录
查看更多内容
影响因子：
8
作者：
Barnes, C;Wong, P;Monagle, P
通讯作者：
Monagle, P
影响因子：
4.1
作者：
Eleftheriou, Kyriacos I.;Rawal, Jaikirty S.;Montgomery, Hugh E.
通讯作者：
Montgomery, Hugh E.
影响因子：
6.7
作者：
Iorio, Alfonso;Fabbriciani, Gianluigi;Filipponi, Paolo
通讯作者：
Filipponi, Paolo
影响因子：
3.5
作者：
Katsarou, Olga;Terpos, Evangelos;Karafoulidou, Anastasia
通讯作者：
Karafoulidou, Anastasia
DOI：
10.1097/gme.0b013e31824ac071
发表时间：
2012-09-01
影响因子：
2.7
作者：
Marrone, Jill A.;Maddalozzo, Gianni F.;Iwaniec, Urszula T.
通讯作者：
Iwaniec, Urszula T.