Protein destabilisation by ruthenium(II) tris-bipyridine based protein-surface mimetics.
Protein destabilisation by ruthenium(II) tris-bipyridine based protein-surface mimetics.
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DOI：
10.1039/c3ob26251k
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发表时间：
2013-04-07
影响因子：
3.2
通讯作者：
Fletcher NC
中科院分区：
文献类型：
--
作者：
Wilson AJ;Ault JR;Filby MH;Philips HI;Ashcroft AE;Fletcher NC
Highly functionalised ruthenium(II) tris-bipyridine receptor 1 which acts as a selective sensor for equine cytochrome c (cyt c) is shown to destabilise the native protein conformation by around 25 °C. Receptors 2 and 3 do not exert this effect confirming the behaviour is a specific effect of molecular recognition between 1 and cyt c, whilst the absence of a destabilising effect on 60% acetylated cyt c demonstrates the behaviour of 1 to be protein specific. Molecular recognition also modifies the conformational properties of the target protein at room temperature as evidenced by ion-mobility spectrometry (IMS) and accelerated trypsin proteolysis.
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影响因子：
4.3
作者：
Muldoon, James;Ashcroft, Alison E.;Wilson, Andrew J.
通讯作者：
Wilson, Andrew J.
影响因子：
21.8
作者：
通讯作者：
--
影响因子：
15
作者：
Baldini, L;Wilson, AJ;Hamilton, AD
通讯作者：
Hamilton, AD
DOI：
10.1016/j.jasms.2007.09.017
发表时间：
2007-12
影响因子：
3.2
作者：
Smith DP;Giles K;Bateman RH;Radford SE;Ashcroft AE
通讯作者：
Ashcroft AE
DOI：
10.1039/c0cc04754f
发表时间：
2011-01-07
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Filby MH;Muldoon J;Dabb S;Fletcher NC;Ashcroft AE;Wilson AJ
通讯作者：
Wilson AJ