Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase.
Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase.
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DOI：
10.1038/ki.2010.404
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发表时间：
2011-02
影响因子：
19.6
通讯作者：
Bonventre, Joseph V.
中科院分区：
文献类型：
--
作者：
Vaidya, Vishal S.;Niewczas, Monika A.;Ficociello, Linda H.;Johnson, Amanda C.;Collings, Fitz B.;Warram, James H.;Krolewski, Andrzej S.;Bonventre, Joseph V.
1型糖尿病患者的尿白蛋白排泄升高在大多数患者中恢复为正常白蛋白尿，但在一些患者中进展为蛋白尿。为了获得对糖尿病肾病早期病理生理学的有价值的见解，我们评估了1型糖尿病患者肾小管损伤生物标志物与白蛋白尿变化的相关性。对38例健康人和659例伴有不同程度蛋白尿的1型糖尿病患者的尿液进行了肾损伤分子-1（KIM-1）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和一些炎症标志物的检测。尿白细胞介素-6、CXCL 10/IP-10、NAG和KIM-1水平在健康个体中非常低，在正常白蛋白尿的1型患者中升高，在有微量白蛋白尿的糖尿病患者中最高。低基线浓度的尿KIM-1和NAG，无论是单独或共同与微量白蛋白尿在随后的2年的回归显着相关;一个独立的临床特征的效果。微量白蛋白尿的进展和消退与白细胞介素6和8、CXCL 10/IP-10和单核细胞趋化蛋白-1的尿水平无关。因此，我们的研究结果表明，较低的尿KIM-1和NAG水平与1型糖尿病微量白蛋白尿的消退有关。因此，肾小管功能障碍是糖尿病肾病早期病程的关键组成部分。
Elevated urinary albumin excretion in patients with type 1 diabetes reverts to normoalbuminuria in a majority of patients but advances toward proteinuria in some. In order to gain valuable insights into the early pathophysiology of diabetic nephropathy we evaluated the association of kidney tubular injury biomarkers with changes in albuminuria in patients with type 1 diabetes mellitus. Urine levels of kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and some inflammatory markers were determined in 38 healthy individuals and 659 patients with type 1 diabetes mellitus having varying degrees of albuminuria. Urinary interleukin-6, CXCL10/IP-10, NAG, and KIM-1 levels were very low in healthy individuals, increased in type 1 patients with normoalbuminuria, and were highest in diabetic patients that had microalbuminuria. Low baseline concentrations of urinary KIM-1 and NAG both individually and collectively were significantly associated with the regression of microalbuminuria over the subsequent 2 years; an effect independent of clinical characteristics. Progression and regression of microalbuminuria were unrelated to urinary levels of interleukins 6 and 8, CXCL10/IP-10, and monocyte chemoattractant protein-1. Thus our results show that lower urinary KIM-1 and NAG levels were associated with the regression of microalbuminuria in type 1 diabetes mellitus. Hence, tubular dysfunction is a critical component of the early course of diabetic nephropathy.
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影响因子：
19.6
作者：
Vaidya, Vishal S.;Ford, Glen M.;Waikar, Sushrut S.;Wang, Yizhuo;Clement, Matthew B.;Ramirez, Victoria;Glaab, Warren E.;Troth, Sean P.;Sistare, Frank D.;Prozialeck, Walter C.;Edwards, Joshua R.;Bobadilla, Norma A.;Mefferd, Stephen C.;Bonventre, Joseph V.
通讯作者：
Bonventre, Joseph V.
影响因子：
3.5
作者：
MacIsaac, R. J.;Tsalamandris, C.;Jerums, G.
通讯作者：
Jerums, G.
影响因子：
19.6
作者：
Bonventre, JV;Zuk, A
通讯作者：
Zuk, A
影响因子：
4.8
作者：
Ichimura, T;Bonventre, JV;Sanicola, M
通讯作者：
Sanicola, M
影响因子：
19.6
作者：
Han, WK;Bailly, V;Bonventre, JV
通讯作者：
Bonventre, JV