Reduced Memory Coherence for Negative Events and Its Relationship to Posttraumatic Stress Disorder.
Reduced Memory Coherence for Negative Events and Its Relationship to Posttraumatic Stress Disorder.
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DOI：
10.1177/0963721420917691
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发表时间：
2020-06
影响因子：
7.2
通讯作者：
Brewin CR
中科院分区：
文献类型：
--
作者：
Bisby JA;Burgess N;Brewin CR
创伤后应激障碍（PTSD）的特征是记忆中断，包括不自觉地重新经历创伤的生动感觉图像。然而，创伤故意记忆中断的程度和性质仍然存在争议。一个单一的解释假定，创伤事件的记忆的各个方面都得到了加强。相反，双重表征的帐户提出了上调的感觉和情感表征的负面内容和下调的海马表示的事件发生的背景。我们采取神经科学的方法，并审查有关产生连贯的情景记忆所需的机制，以及它们是如何在涉及负面内容的实验中受到影响的文献。我们发现，在健康的志愿者，负面的内容可以减少关联绑定和连贯性的情景记忆。最后，我们将这些研究结果与PTSD的文献结合起来，以突出患者中类似的联想机制是如何受到影响的，与海马损伤一致，支持记忆连贯性中断的双重表征观点。
Posttraumatic stress disorder (PTSD) is characterized by disruptions in memory, including vivid sensory images of the trauma that are involuntarily reexperienced. However, the extent and nature of disruptions to deliberate memory for trauma remain controversial. A unitary account posits that all aspects of memory for a traumatic event are strengthened. In contrast, a dual-representation account proposes up-modulation of sensory and affective representations of the negative content and down-modulation of hippocampal representations of the context in which the event occurred. We take a neuroscientific approach and review the literature concerning the mechanisms required to produce coherent episodic memories and how they are affected in experiments involving negative content. We find, in healthy volunteers, that negative content can reduce associative binding and the coherence of episodic memories. Finally, we bring these findings together with the literature on PTSD to highlight how similar associative mechanisms are affected in patients, consistent with hippocampal impairment, supporting a dual-representation view of disrupted memory coherence.
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DOI：
10.1101/lm.032409.113
发表时间：
2013-12-17
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Bisby JA;Burgess N
通讯作者：
Burgess N
影响因子：
16.6
作者：
Horner AJ;Bisby JA;Bush D;Lin WJ;Burgess N
通讯作者：
Burgess N
负面情绪内容破坏了情节记忆的连贯性。
DOI：
10.1037/xge0000356
发表时间：
2018-03
期刊：
Journal of experimental psychology. General
影响因子：
--
作者：
Bisby JA;Horner AJ;Bush D;Burgess N
通讯作者：
Burgess N
影响因子：
25
作者：
Gilbertson, MW;Shenton, ME;Pitman, RK
通讯作者：
Pitman, RK
影响因子：
4.1
作者：
Horner, Aidan J.;Burgess, Neil
通讯作者：
Burgess, Neil