Cognitive Effects of Cancer and Cancer Treatments.
Cognitive Effects of Cancer and Cancer Treatments.
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DOI：
10.1146/annurev-clinpsy-050817-084903
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发表时间：
2018-05-07
影响因子：
18.4
通讯作者：
Root, James C.
中科院分区：
文献类型：
--
作者：
Ahles, Tim A.;Root, James C.
关键词：
随着癌症幸存者的人数增加到数百万，人们越来越重视了解治疗的晚期效应如何影响幸存者重返工作/学校的能力，他们的功能和独立生活的能力以及他们的整体生活质量。本文综述了与癌症和癌症治疗相关的认知变化。这一领域的研究已经从药物毒理学的角度发展到将认知变化视为治疗各方面的复杂相互作用，增加治疗后认知下降风险的脆弱性因素，癌症生物学和衰老生物学。方法学方面的进展包括：（a）开发了基于认知神经科学评估认知的更细粒度子成分的测量方法;（B）开发了先进的统计方法。从这个多层面的角度所产生的概念问题，描述了未来的方向，了解机制，创新干预措施的发展。
As the population of cancer survivors has grown into the millions, there has been increasing emphasis on understanding how the late effects of treatment affect survivors’ ability to return to work/school, their capacity to function and live independently, and their overall quality of life. This review focuses on cognitive change associated with cancer and cancer treatments. Research in this area has progressed from a pharmacotoxicology perspective to a view of the cognitive change as a complex interaction of aspects of the treatment, vulnerability factors that increase risk for posttreatment cognitive decline, cancer biology, and the biology of aging. Methodological advances include the development of (a) measurement approaches that assess more fine-grained subcomponents of cognition based on cognitive neuroscience and (b) advanced statistical approaches. Conceptual issues that arise from this multidimensional perspective are described in relation to future directions, understanding of mechanisms, and development of innovative interventions.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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作者：
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Silberfarb, PM
DOI：
10.1111/j.1532-5415.2008.02136.x
发表时间：
2009-03-01
影响因子：
6.3
作者：
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通讯作者：
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