Shifting Developmental Trajectories During Critical Periods of Brain Formation.
Shifting Developmental Trajectories During Critical Periods of Brain Formation.
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DOI：
10.3389/fncel.2020.00283
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发表时间：
2020
影响因子：
5.3
通讯作者：
Del Pino I
中科院分区：
文献类型：
--
作者：
Dehorter N;Del Pino I
大脑发育的关键时期是由正常大脑功能所必需的环境影响驱动的可塑性增强的时期。最近的研究开始揭示这样一种可能性，即在关键时期进行及时干预有可能重新调整神经和神经精神疾病动物模型中的异常发育轨迹。在这篇综述中，我们重新审视了定义关键期的标准，强调了最近发现的健康和疾病发育可塑性机制。此外，我们还讨论了体外人源神经网络关键时期建模的技术改进。这些与在动物模型的未成熟大脑中使用发育操作相关的科学进展是基本的临床前系统，它将允许未来将及时干预转化为神经发育障碍（例如智力障碍、自闭症谱系障碍（ASD）和精神分裂症）的临床应用。
Critical periods of brain development are epochs of heightened plasticity driven by environmental influence necessary for normal brain function. Recent studies are beginning to shed light on the possibility that timely interventions during critical periods hold potential to reorient abnormal developmental trajectories in animal models of neurological and neuropsychiatric disorders. In this review, we re-examine the criteria defining critical periods, highlighting the recently discovered mechanisms of developmental plasticity in health and disease. In addition, we touch upon technological improvements for modeling critical periods in human-derived neural networks in vitro. These scientific advances associated with the use of developmental manipulations in the immature brain of animal models are the basic preclinical systems that will allow the future translatability of timely interventions into clinical applications for neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD) and schizophrenia.
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影响因子：
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通讯作者：
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