Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.
Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.
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DOI：
10.1016/j.ijpddr.2014.07.007
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发表时间：
2014-12
影响因子：
4
通讯作者：
Prichard, Roger K.
中科院分区：
文献类型：
--
作者：
Kotze, Andrew C.;Hunt, Peter W.;Skuce, Philip;von Samson-Himmelstjerna, Georg;Martin, Richard J.;Sager, Heinz;Kruecken, Juergen;Hodgkinson, Jane;Lespine, Anne;Jex, Aaron R.;Gilleard, John S.;Beech, Robin N.;Wolstenholme, Adrian J.;Demeler, Janina;Robertson, Alan P.;Charvet, Claude L.;Neveu, Cedric;Kaminsky, Ronald;Rufener, Lucien;Alberich, Melanie;Menez, Cecile;Prichard, Roger K.
我们报告了2013年驱虫药耐药性和敏感性会议。介绍了抗蠕虫药物抗性标记鉴定的最新进展。苯并咪唑抗性标记在兽医和人类线虫田间研究中的应用。最新高通量测序技术在驱虫药耐药性研究中的应用。抗蠕虫药耐药性对全球畜牧业生产系统产生重大影响，是伴侣动物医学中一个新出现的问题，并对我们控制人类土壤传播蠕虫的持续能力构成威胁。驱虫药抗性和敏感性联盟（汽车）为科学家提供了一个论坛，以讨论寻找驱虫药抗性分子标记的最新进展。这些标记物对于检测抗药性蠕虫种群和指示抗药性对药物功效的可能影响是重要的。耐药性的分子基础对于理解驱虫药如何起作用以及耐药群体如何产生也很重要。可能涉及靶受体、药物外排和其他生物学过程的变化。本文报道了2013年8月在澳大利亚珀斯举行的汽车小组会议。本文综述了抗蠕虫药物分子标记的最新进展。耐药性的分子基础是最好的理解苯并咪唑组的化合物，我们研究了最近的工作，将这些知识转化为有用的诊断领域使用。我们研究了最近的候选基因和全基因组方法，以了解驱虫剂的耐药性和识别标记。我们还研究了药物转运蛋白，为耐药性提供了有用的标志物，以及通过抑制剂靶向转运蛋白本身来克服耐药性的机会。最后，我们描述了最新的高通量测序技术的应用，驱虫药耐药性的研究工具。
We report on the Consortium for Anthelmintic Resistance and Susceptibility 2013 meeting. Recent advances in the identification of markers for anthelmintic resistance are described. The use of markers for benzimidazole resistance in field studies with veterinary and human nematodes. The application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance. Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS) provides a forum for scientists to meet and discuss the latest developments in the search for molecular markers of anthelmintic resistance. Such markers are important for detecting drug resistant worm populations, and indicating the likely impact of the resistance on drug efficacy. The molecular basis of resistance is also important for understanding how anthelmintics work, and how drug resistant populations arise. Changes to target receptors, drug efflux and other biological processes can be involved. This paper reports on the CARS group meeting held in August 2013 in Perth, Australia. The latest knowledge on the development of molecular markers for resistance to each of the principal classes of anthelmintics is reviewed. The molecular basis of resistance is best understood for the benzimidazole group of compounds, and we examine recent work to translate this knowledge into useful diagnostics for field use. We examine recent candidate-gene and whole-genome approaches to understanding anthelmintic resistance and identify markers. We also look at drug transporters in terms of providing both useful markers for resistance, as well as opportunities to overcome resistance through the targeting of the transporters themselves with inhibitors. Finally, we describe the tools available for the application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance.
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影响因子：
64.8
作者：
CULLY, DF;VASSILATIS, DK;ARENA, JP
通讯作者：
ARENA, JP
影响因子：
4
作者：
Barrere, Virginie;Beech, Robin N.;Prichard, Roger K.
通讯作者：
Prichard, Roger K.
DOI：
10.1016/j.trstmh.2005.03.019
发表时间：
2007-12-01
影响因子：
2.2
作者：
Ardelli, B. F.;Prichard, R. K.
通讯作者：
Prichard, R. K.
影响因子：
7.3
作者：
Boulin, T.;Fauvin, A.;Neveu, C.
通讯作者：
Neveu, C.
影响因子：
5
作者：
Adelsberger, H;Lepier, A;Dudel, J
通讯作者：
Dudel, J